Results 101 to 110 of about 2,813,819 (368)

Hydrogen bond network topology in liquid water and methanol: a graph theory approach [PDF]

, 2013
Networks are increasingly recognized as important building blocks of various systems in nature and society. Water is known to possess an extended hydrogen bond network, in which the individual bonds are broken in the sub-picosecond range and still the ...
Abascal, Albert, Bako, Bakó, Barabási, Barahona, Berendsen, Blumberg, Boccaletti, Chihaia, Chung, da Silva, da Silva, Dorogovtsev, Dorogovtsev, dos Santos, Erdős, Erdős, Errington, Errington, Farkas, Fiedler, Forster, Geiger, Gómez-Álvarez, Holzmann, Imre Bakó, Jan, Jeong, Jorgensen, Julianna Oláh, Kersti Hermannson, Kim, Kim, Kiss, Kiss, Kuhn, Kumar, Kumar, Lehota, Luzar, Luzar, Ma, Matsumoto, Matsumoto, Mcgraw, Megyes, Mitrowic, Mura, Newmann, Oleinikova, Onnela, Pálinkás, Samuhkin, Schmidt, Schmidt, Sciortiono, Stanley, Stanley, Szabolcs Bálint, Tamás Grósz, Timothy, Viorel Chihaia, Vrhovsek, Watts, Wigner, Wigner, Wigner, Ákos Bencsura   +68 more
core   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Exploring the frontiers of condensed-phase chemistry with a general reactive machine learning potential

Nature Chemistry
Atomistic simulation has a broad range of applications from drug design to materials discovery. Machine learning interatomic potentials (MLIPs) have become an efficient alternative to computationally expensive ab initio simulations.
Shuhao Zhang, Małgorzata Z. Makoś, Ryan B Jadrich, E. Kraka, Kipton Barros, B. Nebgen, Sergei Tretiak, O. Isayev, N. Lubbers, Richard A. Messerly, Justin S. Smith   +10 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Dualism of Remarkable Magnesium Ion Conduction with Low Activation Energy over a Wide Temperature Range versus Limited Stability of the Hybrid Composite Electrolyte Mg‐MOF‐74/MgX2/Propylene Carbonate

Advanced Energy & Sustainability Research
A metal–organic framework (MOF) quasi‐solid‐state Mg2+‐ion conductor is prepared with a conductivity of 0.6 × 10−4 S cm−1 already at room temperature. Mg‐MOF‐74 acts as host for MgX2 (X = Cl−, Br−, BF4−) dissolved in propylene carbonate, leading to dry ...
Ruben Maile, Zhixuan Wei, Andreas Johannes Achazi, Kangli Wang, Pascal Henkel, Doreen Mollenhauer, Jürgen Janek, Klaus Müller‐Buschbaum   +7 more
doaj   +1 more source

meta-Oligoazobiphenyls – synthesis via site-selective Mills reaction and photochemical properties

Beilstein Journal of Organic Chemistry, 2012
The investigation of multi-photochromic compounds constitutes a great challenge, not only from a synthetic point of view, but also with respect to the analysis of the photochemical properties.
Raphael Reuter, Hermann A. Wegner
doaj   +1 more source

Group 13 Decamethylmetallocenium Cations [PDF]

, 2007
Salts containing the decamethylmetallocenium cations, [( C5Me5) M-2](+) ( or Cp*M-2(+)) of the group 13 "metals" B, Al and Ga have been prepared using a variety of synthetic routes.
Cowley, Alan H., Filipponi, Silvia, Gorden, John D., Macdonald, Charles L. B., Voigt, Andreas   +4 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells

Data in Brief, 2015
The endo-lysosomal cysteine cathepsin L has recently been shown to have moonlighting activities in that its unexpected nuclear localization in colorectal carcinoma cells is involved in cell cycle progression (Tamhane et al., 2015) [1]. Here, we show data
Tripti Tamhane, Brit K. Wolters, Rukshala Illukkumbura, Gunhild M. Maelandsmo, Mads H. Haugen, Klaudia Brix   +5 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source