Results 91 to 100 of about 108,684 (302)
Successive Ring Expansion (SuRE) in the synthesis of medium sized ring and macrocycle libraries [PDF]
, 2023 This thesis describes the development of new methodologies to synthesize different medium sized rings and macrocycles, either using Successive Ring Expansion (SuRE) reactions or SuRE-like reactions.
Yang, Zhongzhen
core
Strain‐driven, non‐catalysed ring expansion of silicon heterocycles
, 2023 Silacycles are ubiquitous building blocks. Small silacycles can typically be expanded catalytically. A silirane, silirene and phosphasilirene as well as a siletane and a silolene were prepared starting from the base-free bromosilylene [($^{dtbp}$Cbz)SiBr]
Hinz, Alexander, Müller, Maximilian P.
core +1 more source
Journal of Synthetic Organic Chemistry, Japan, 1993 Ring expansion reaction is one of the excellent methods for construction of medium- and large sized cyclic compounds. In present review, the so-called “zip” ring expansion has been focussed to synthesize carbocyclic or heterocyclic compounds. The reaction proceeds under a basic media (or radical process) via one-pot two-steps sequence from α, α ...
Kiyoshi SAKAI, Zhuo-Feng Xie
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Ring-Contraction vs Ring-Expansion Reactions of Spiro-cyclopropanecarboxylated Sugars
, 2016 Electrophilic ring opening of spiro-cyclopropanecarboxylated sugars followed by reaction with DBU revealed interesting ring-contraction and ring-expansion reactions depending on the substrate and the kind of hydroxyl protective group present adjacent to ...
Perali Ramu Sridhar (1916158) +1 more
core +1 more source
Ring-Expansion Reaction of Oximes with Aluminum Reductants
Molecules, 2012 The ring-expansion reactions of heterocyclic ketoximes and carbocyclic ketoximes with several reductants such as AlHCl<sub>2</sub>, AlH<sub>3</sub> (alane), LiAlH<sub>4</sub>, LiAlH(O<em><sup>t</sup> ...
Hidetoshi Tokuyama +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
1-PHOSPHA-2-AZANORBORNENE AS PRECURSOR FOR 1-PHOSPHA-BICYCLO[3.2.1]OCTA-2,5-DIENE
Studia Universitatis Babes-Bolyai Chemia1-Phospha-2-azanorbornenes, the cycloaddition products of 2H-phospholes with a sulfonyl imine, can be converted to 1-phospha-bicyclo[3.2.1]octa-2,5-dienes by a reductive rearrangement.
Peter WONNEBERGER +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source