Results 81 to 90 of about 108,684 (302)
, 2022 We report enantioselective one-carbon ring expansion of aziridines to make azetidines as a new-to-nature activity of engineered ‘carbene transferase’ enzymes.
Frances, Arnold +3 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
ChemistryOpenNovel tetrahydroisoquinoline and piperidine derivatives were selectively synthesized from substituted indenes or cyclopentenes. The process starts with an oxidative cleavage of the ring olefin bond, which gives reactive diformyl intermediates.
Anas Semghouli +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Manganese-Catalyzed Cycloalkene Ring Expansion Synthesis of Azaheterocycles
Radical chemistry is synthetically useful but can be plagued by the non-intuitive reaction course and indiscriminate reactivity profile. Herein, dynamic radical effect is revealed as a conceptual logic for the predictive achievement of radical reaction ...
Jin, Zhu +4 more
core +1 more source
Shortcut Approach to 1,4-Diazepine from 3-Pyridylnitrene Intermedietes under Mild Condition
Journal of Pure and Applied Chemistry Research, 2014 The reaction of nitropyridine derivatives and tributylphosphine (Bu3P) with the existence of nucleophilic solvent gives ring expansion product as diazepines in medium yield.
Siti Mariyah Ulfa +2 more
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Successive Ring Expansion Reactions [PDF]
, 2019 This thesis describes the development of a series of methods for performing ring expansion reactions consecutively, either using successive reactions (explored in Chapters 2–4) or cascade sequences (explored in Chapters 5 and 6).
Stephens, Tom
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Ring Expansion via Olefin Metathesis [PDF]
, 2002 Various macrocycles were prepared in one step by a novel ring-expansion method using olefin ...
Choi, Tae-Lim +2 more
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