Results 201 to 210 of about 18,020 (210)

RIPK1 and RIPK3 form mosaic necrosomes

Nature Cell Biology, 2022
Weiwei Qi, Junying Yuan
openaire   +2 more sources

PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats

Experimental Neurology
Neuronal death plays a crucial role in early brain injury after subarachnoid hemorrhage (SAH). PANoptosis is a programmed form of cell death regulated by the PANoptosome, which possesses key characteristics of pyroptosis, apoptosis and necroptosis. Phosphoglycerate mutase family member 5 (PGAM5) has specific phosphatase activity that phosphorylates or ...
Duan, Jiajia, Yuan, Wen, Jiang, Enyan, Zhang, Xiaojian, Fang, Zhen, Zeng, Jia, Wang, Jikai, Yan, Xiaoxin, Liu, Aihua, Kong, Fangen, Liu, Fei   +10 more
openaire   +2 more sources

A novel RIPK1 inhibitor attenuates GVHD

Blood, 2023
Geoffrey R, Hill, Motoko, Koyama
openaire   +2 more sources

Hypoxia-stabilized RIPK1 promotes cell death

Nature Cell Biology, 2023
Wei Ruan, Holger K. Eltzschig, Xiaoyi Yuan   +2 more
openaire   +2 more sources

Monitoring RIPK1 Phosphorylation in the TNFR1 Signaling Complex

2018
Receptor-interacting protein kinase 1 (RIPK1) is a component of the TNFR1 signaling complex (also known as complex I or TNFR-SC), where its ubiquitylation by cIAP1/2 and LUBAC serves to initiate prosurvival and proinflammatory responses through activation of the MAPK and NF-κB pathways. IKKα/β-mediated phosphorylation of RIPK1 in complex I was shown to
Dario, Priem, Yves, Dondelinger, Mathieu J M, Bertrand   +2 more
openaire   +2 more sources

Sanofi buys into Denali’s RIPK1 drugs

C&EN Global Enterprise, 2018
In another sizable deal for Denali Therapeutics, Sanofi is paying $125 million to buy into a series of neuroinflammation compounds called RIPK1 inhibitors. The pact provides key funding for the molecules, which have potential activity across several diseases with large patient populations, including Alzheimer’s, multiple sclerosis, and arthritis.
openaire   +1 more source

RIPK1 Gene

2020
openaire   +1 more source

RIPK1, a key survival factor for hepatocytes

Journal of Hepatology, 2017
Bleriot, Camille, Lecuit, Marc
openaire   +3 more sources

Metabolic regulation of RIPK1

Nature Cell Biology
openaire   +1 more source

RIPK1 and necroptosis role in premature ageing

Nature Cell Biology
Panxue Wang, John Silke
openaire   +2 more sources