Results 211 to 220 of about 18,314 (233)
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Hypoxia-stabilized RIPK1 promotes cell death
Nature Cell Biology, 2023Wei Ruan +2 more
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Monitoring RIPK1 Phosphorylation in the TNFR1 Signaling Complex
2018Receptor-interacting protein kinase 1 (RIPK1) is a component of the TNFR1 signaling complex (also known as complex I or TNFR-SC), where its ubiquitylation by cIAP1/2 and LUBAC serves to initiate prosurvival and proinflammatory responses through activation of the MAPK and NF-κB pathways. IKKα/β-mediated phosphorylation of RIPK1 in complex I was shown to
Dario, Priem +2 more
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Sanofi buys into Denali’s RIPK1 drugs
C&EN Global Enterprise, 2018In another sizable deal for Denali Therapeutics, Sanofi is paying $125 million to buy into a series of neuroinflammation compounds called RIPK1 inhibitors. The pact provides key funding for the molecules, which have potential activity across several diseases with large patient populations, including Alzheimer’s, multiple sclerosis, and arthritis.
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Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death
Nature Reviews Molecular Cell Biology, 2023Jarama Clucas, Pascal Meier
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Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
Nature Reviews Drug Discovery, 2020Lauren Mifflin, Junying Yuan
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RIPK1, a key survival factor for hepatocytes
Journal of Hepatology, 2017Bleriot, Camille, Lecuit, Marc
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Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1
Science, 2023Tao Zhang, Daichao Xu, Elijah Trefts
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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
Cell, 2018Daichao Xu, Hong Zhu, Hongbo Chen
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The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex
Cell, 2018Miguel Mompeán +2 more
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