Results 221 to 230 of about 19,353 (245)

Human cytomegalovirus-triggered necroptosis is suppressed by sequestration of MLKL in the nucleus of infected monocytes. [PDF]

J Virol
Geiler BW, Moradpour S, Chauder BB, Akter D, Chan GC.   +4 more
europepmc   +1 more source

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk. [PDF]

Front Pharmacol
Tu Y, Liu W, Sang T, Pan L, Wu W, Fang Q, Liu Y, Liu B, Wan Y.   +8 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

RIPK1 and RIPK3 in antibacterial defence

Biochemical Society Transactions, 2022
Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by either driving inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis,
Hui Wen Yeap, Kaiwen W. Chen
openaire   +2 more sources

Mechanisms of RIPK3‐induced inflammation

Immunology & Cell Biology, 2017
Receptor‐interacting protein kinase 3 (RIP3/RIPK3) is a multifunctional regulator of cell death and inflammation. It controls signalling downstream of the tumor necrosis factor (TNF) receptor family, DNA‐dependent activator of IFN‐regulatory factors (DAI) and toll‐like receptors (TLRs).
Inbar Shlomovitz, Sefi Zargrian, Motti Gerlic   +2 more
openaire   +2 more sources

Ring closure strategy leads to potent RIPK3 inhibitors

European Journal of Medicinal Chemistry, 2021
Necroptosis is a form of regulated necrotic cell death that is independent of caspases. Receptor-interacting protein kinase 3 (RIPK3) has been identified as a key regulator for necroptosis, and has been proposed as a potential therapeutic target for the treatment of diseases associated with necroptosis. In this report, we describe the design, synthesis,
Shuwei, Wu, Chen, Xu, Kaijiang, Xia, Yu, Lin, Sheng, Tian, Haikuo, Ma, Yuting, Ji, Fang, Zhu, Sudan, He, Xiaohu, Zhang   +9 more
openaire   +2 more sources

c-Abl activates RIPK3 signaling in Gaucher disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021
Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. Heterozygous GBA1 variants are a major genetic risk factor for developing Parkinson's disease.
Yañez Henríquez, María José, Campos, F., Marín Marín, Tamara Alejandra, Klein Posternack, Andrés David, Futerman, A. H., Álvarez, Alejandra R., Zanlungo Matsuhiro, Silvana   +6 more
openaire   +3 more sources

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

Trends in Pharmacological Sciences, 2020
The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates prosurvival signaling and inflammatory gene expression, while its kinase activity mediates both apoptosis and necroptosis; the latter involving RIPK3 kinase activity.
Martens, Sofie, Hofmans, Sam, Declercq, Wim, Augustyns, Koen, Vandenabeele, Peter   +4 more
openaire   +3 more sources

The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection.

Immunity
While recent work has identified roles for immune mediators in regulating neural activity, how innate immune signaling within neurons influences neurotransmission remains poorly understood.
Irving Estevez, Benjamin D. Buckley, Marissa Lindman, Nicholas Panzera, Tsui-Wen Chou, Micheal McCourt, Brandon J. Vaglio, Colm Atkins, Bonnie L Firestein, Brian P. Daniels   +9 more
semanticscholar   +1 more source

Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death.

Biomaterials
Necroptotic immunogenic cell death (ICD) can activate the human immune system to treat the metastasis and recurrence of triple-negative breast cancer (TNBC). However, developing the necroptotic inducer and precisely delivering it to the tumor site is the
Jiahao Liang, Xiangge Tian, Meirong Zhou, Fei Yan, Jialong Fan, Yan Qin, Binlong Chen, Xiaokui Huo, Zhenlong Yu, Yan Tian, Sa Deng, Yulin Peng, Yan Wang, Bin Liu, Xiaochi Ma   +14 more
semanticscholar   +1 more source