Results 31 to 40 of about 3,611 (194)
Tzu Chi Medical Journal, 2021 Targeted therapy aiming at the metastatic signal pathway, such as that triggered by receptor tyrosine kinase (RTK), for the prevention of tumor progression is promising.
Chi-Tan Hu +2 more
doaj +1 more source
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP [PDF]
, 1999 Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different cell types.
A Minden +25 more
core +1 more source
Molecular and cellular paradigms of multidrug resistance in cancer
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya +6 more
wiley +1 more source
Analysis of signalling pathways using continuous time Markov chains [PDF]
, 2006 We describe a quantitative modelling and analysis approach for signal transduction networks. We illustrate the approach with an example, the RKIP inhibited ERK pathway [CSK+03].
A. Aziz +12 more
core +3 more sources
Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives
Exploration, Volume 2, Issue 5, October 2022., 2022 This review takes a critical look at four key gasotransmitters (CO, NO, H2S and SO2) with their incorporation into prodrugs known as gas‐releasing molecule. Different nanosystems and their mediatory roles for efficient shuttling, targeting and cleavage of therapeutic gases and the responsiveness to typical internal and external stimuli for gas release ...
Yaw Opoku‐Damoah +3 more
wiley +1 more source
BMC Cancer, 2011 Background Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of ...
Chia David +11 more
doaj +1 more source
Computational models for inferring biochemical networks [PDF]
, 2014 Biochemical networks are of great practical importance. The interaction of biological compounds in cells has been enforced to a proper understanding by the numerous bioinformatics projects, which contributed to a vast amount of biological information ...
Crina Grosan +20 more
core +1 more source
Experimental Dermatology, Volume 31, Issue 10, Page 1563-1578, October 2022., 2022 Abstract Melanoma has a higher mortality rate than any other skin cancer, and its cases are increasing. The transcription factor YY1 has been proven to be involved in tumour progression; however, the role of YY1 in melanoma is not well understood. This study investigates how YY1 functions in melanoma progression, and it also elucidates the underlying ...
Shumin Zhou +4 more
wiley +1 more source
RKIP: A Pivotal Gene Product in the Pathogenesis of Cancer. [PDF]
Cancers (Basel), 2022 Raf kinase inhibitor protein (RKIP), previously known as a phosphatidylethanolamine-binding protein (PEBP), was cloned by Yeung et al [...]
Bonavida B.
europepmc +5 more sources
An integrative top-down and bottom-up qualitative model construction framework for exploration of biochemical systems [PDF]
, 2014 The authors would like to thank the support on this research by the CRISP project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer ...
Coghill, George M, Pang, Wei, Wu, Zujian
core +2 more sources