Results 41 to 50 of about 3,611 (194)
Raf kinase inhibitory protein reduces bradykinin receptor desensitization
Journal of Neurochemistry, Volume 162, Issue 2, Page 156-165, July 2022., 2022 In this study, we investigated unknown biochemical modulators that may contribute to persistent inflammation. We identified that small, physiological concentrations of bradykinin can stimulate protein kinase C (PKC) activity, to increase phosphorylation of Raf Kinase Inhibitory Protein (RKIP) and its association with GPCR Receptor Kinase 2 (GRK2 ...
Samuel B. Chivers +2 more
wiley +1 more source
Intermediates and Generic Convergence to Equilibria [PDF]
, 2017 Known graphical conditions for the generic or global convergence to equilibria of the dynamical system arising from a reaction network are shown to be invariant under the so-called successive removal of intermediates, a systematic procedure to simplify ...
de Freitas, Michael Marcondes +2 more
core +2 more sources
Frontiers in Medicine, 2019 Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e.,
Stefan Wolf +3 more
doaj +1 more source
PEBP1/RKIP behavior: a mirror of actin-membrane organization [PDF]
Cellular and Molecular Life Sciences, 2020 Phosphatidylethanolamine-binding protein 1 (PEBP1), a small 21 kDa protein, is implicated in several key processes of the living cell. The deregulation of PEBP1, especially its downregulation, leads to major diseases such as cancer and Alzheimer's disease.
Schoentgen, Françoise, Jonic, Slavica
openaire +3 more sources
Cellular Physiology and Biochemistry, 2017 Background: Acute ischemic stroke is one of the most important factors leading to disability and death with the characterization of accumulated neuron death and injured supportive neurovascular structures.
Li Su +4 more
doaj +1 more source
A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. [PDF]
PLoS ONE, 2012 Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy.
Fahd Al-Mulla +4 more
doaj +1 more source
Estimating Network Kinetics of the MAPK/ERK Pathway Using Biochemical Data [PDF]
, 2012 The MAPK/ERK pathway is a major signal transduction system which regulates many fundamental cellular processes including the growth control and the cell death.
Purutçuoğlu, Vilda,, Wit, Ernst,
core +6 more sources
Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population. [PDF]
PLoS ONE, 2014 BACKGROUND: Raf-1 kinase inhibitor protein (RKIP) plays a critical role in tumor development by regulating cell functions such as invasion, apoptosis and differentiation.
Qiang Cao +15 more
doaj +1 more source
Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra PEPA [PDF]
, 2006 This paper examines the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signalling pathway [5] through modelling in a Markovian process algebra, PEPA [11].
A. Aziz +13 more
core +3 more sources
Haematologica, 2020 RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias.
Veronica Caraffini +19 more
doaj +1 more source