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Closing the circle : current state and perspectives of circular RNA databases [PDF]
, 2021 Circular RNAs (circRNAs) are covalently closed RNA molecules that have been linked to various diseases, including cancer. However, a precise function and working mechanism are lacking for the larger majority.
Vandesompele, Jo +2 more
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Cell-type specific features of circular RNA expression. [PDF]
PLoS Genetics, 2013 Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using an improved computational approach for circular RNA identification, we found widespread circular
Julia Salzman +4 more
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RNA Biology, 2019 Formed by back splicing or back fusion of linear RNAs, circular RNAs (circRNAs) constitute a new class of non-coding RNAs of eukaryotes. Recent studies reveal a spliceosome-dependent biogenesis of circRNAs where circRNAs arise at the intron-exon junctions of mRNAs.
Xiaoxin Liu +10 more
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Circular RNAs in Toxicology [PDF]
Toxicological Sciences, 2020 Abstract Circular RNAs (circRNAs) are a type of closed, long, non-coding RNAs, which have attracted significant attention in recent years. CircRNAs exhibit unique functions and are characterized by stable expression in various tissues across different species.
Yueting Shao, Yiguo Jiang
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Detecting circular RNA from high-throughput sequence data with de Bruijn graph
BMC Genomics, 2020 Background Circular RNA is a type of non-coding RNA, which has a circular structure. Many circular RNAs are stable and contain exons, but are not translated into proteins.
Xin Li, Yufeng Wu
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BMC Cancer, 2022 Background Liver cirrhosis is a well-known risk factor for hepatocellular carcinoma (HCC). However, some HCC cases can also originate from non-cirrhotic livers.
Hongyu Li +6 more
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Circular RNA in tumor metastasis
Molecular Therapy: Nucleic Acids, 2021 Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment.
Chao Zhang +9 more
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Circular RNA HIPK3: A Key Circular RNA in a Variety of Human Cancers
Frontiers in Oncology, 2020 Circular RNAs (circRNAs), which act as initiators and promoters of various diseases, were thought to be mostly noncoding RNAs (ncRNAs) in eukaryotes, until recent studies confirmed that some circRNAs have the function of encoding proteins.
Jingyuan Wen +5 more
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Nature Communications, 2023 Circular RNAs have been extensively studied in eukaryotes, but their presence and/or biological functionality in bacteria are unclear. Here, we show that a regulatory noncoding RNA (DucS) exists in both linear and circular conformation in Bacillus ...
Ting-Ting He +10 more
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Research progress on regulatory mechanisms of circular RNA nuclear receptor interacting protein 1 in tumor occurrence and development [PDF]
Jichu yixue yu linchuang, 2023 Circular RNA (circRNA) is a class of single-stranded covalently closed non-coding RNA molecules widely expressed in eukaryotic cells. Recent studies have found that circRNA has been involved in modulating biological processes such as cell proliferation ...
GAO Xin, YU Yongbo, WANG Haicun, JIANG Xingming, WANG Zhidong
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