Results 11 to 20 of about 298,718 (298)
Circular RNA: Biosynthesis in vitro
Frontiers in Bioengineering and Biotechnology, 2021 Circular RNA (circRNA) is a unique type of noncoding RNA molecule. Compared with traditional linear RNA, circRNA is a covalently closed circle produced by a process called backsplicing.
Xinjie Chen, Yuan Lu
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CIRCULAR RNA – miRNA MEDIATED INTERACTION IN MYOCARDIAL INFARCTION [PDF]
Journal of IMAB, 2021 Circular RNA (circRNAs) belong to the long non-coding RNA family, but unlike the linear RNA in circular RNA, the 3’ and 5’ end in the RNA molecule are joined together, forming their circular structure.
Yordanka Doneva +5 more
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Molecular Therapy - Nucleic Acids, 2019 Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species.
Duc-Hiep Bach +2 more
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Circular RNAs—The Road Less Traveled
Frontiers in Molecular Biosciences, 2020 Circular RNAs are the most recent addition in the non-coding RNA family, which has started to gain recognition after a decade of obscurity. The first couple of reports that emerged at the beginning of this decade and the amount of evidence that has ...
Ashirbad Guria +3 more
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Research progress of circular RNA zinc finger RNA binding protein in malignant tumors [PDF]
Jichu yixue yu linchuang, 2022 Circular RNA is a kind of RNA molecule with special covalent closed circular structure. The existing research results showed that circular RNA zinc finger RNA binding protein (circRNA-ZFR) was abnormally expressed in many malignant tumors, and its ...
LIU Lang, WANG Hai-cun, GAO Xin, LIU Guang-lin, ZHAO Yu-qiao, JIANG Xing-ming
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Frontiers in Immunology, 2022 Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded RNA viruses generate functional circular DNAs is still unknown. Using circDNA sequencing, divergent PCR, DNA in
Min Zhu +13 more
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CircMarker: a fast and accurate algorithm for circular RNA detection
BMC Genomics, 2018 Background While RNA is often created from linear splicing during transcription, recent studies have found that non-canonical splicing sometimes occurs. Non-canonical splicing joins 3’ and 5’ and forms the so-called circular RNA.
Xin Li +4 more
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Circular RNA in gastric cancer
Chinese Medical Journal, 2020 . Gastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor.
Xue-Wei Li +3 more
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What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses
Molecular Therapy: Nucleic Acids, 2022 Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by in vitro transcription and ligation. Formerly,
Janina Breuer +6 more
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Biogenesis of Circular RNAs [PDF]
Cell, 2014 Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences.
Vicens, Quentin, Westhof, Eric
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