Results 31 to 40 of about 298,718 (298)

CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin

Frontiers in Bioinformatics, 2022
Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of ...
Annelien Morlion, Annelien Morlion, Eva Hulstaert, Eva Hulstaert, Marieke Vromman, Marieke Vromman, Jasper Anckaert, Jasper Anckaert, Celine Everaert, Celine Everaert, Jo Vandesompele, Jo Vandesompele, Pieter Mestdagh, Pieter Mestdagh   +13 more
doaj   +1 more source

A small RNA response at DNA ends in Drosophila [PDF]

, 2012
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy, Förstemann, Klaus, Michalik, Katharina M.   +2 more
core   +1 more source

Engineering circular RNA regulators to specifically promote circular RNA production

Theranostics, 2021
Background: A large number of circular RNAs (circRNAs) have been discovered in the mammalian transcriptome with high abundance, which play vital roles in gene regulation, thereby participating in the development of multiple diseases. However, the biogenesis, regulation, and especially manipulation of circRNAs still remain largely unknown.
Qi, Yangfan, Han, Wei, Chen, Dan, Zhao, Jinyao, Bai, Lu, Huang, Fang, Dai, Zhenwei, Li, Gang, Chen, Chaoqun, Zhang, Wenjing, Zhang, Jinrui, Jin, Bilian, Wang, Yang   +12 more
openaire   +2 more sources

Circular RNA—Is the Circle Perfect?

Biomolecules, 2021
Circular RNA (circRNA) is a distinct class of non-coding RNA produced, in principle, using a back-splicing mechanism, conserved during evolution, with increased stability and a tissue-dependent expression.
Lavinia Caba, Laura Florea, Cristina Gug, Daniela Cristina Dimitriu, Eusebiu Vlad Gorduza   +4 more
doaj   +1 more source

Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy [PDF]

, 2019
Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal cell carcinoma (ccRCC) has yet to be conducted. Therefore, the objective of this study was to identify and validate circRNAs in
Erbersdobler, Andreas, Fendler, Annika, Franz, Antonia, Jung, Klaus, Jung, Monika, Kilic, Ergin, Ralla, Bernhard, Rochow, Hannah, Stephan, Carsten, Weickmann, Sabine   +9 more
core   +2 more sources

Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration

Experimental and Molecular Medicine, 2018
Spinal disease: Circular RNA linked to disc degeneration A circular RNA molecule helps protect against degenerative disc disease. Hua Wang and coworkers from Sun Yat-Sen University in Guangzhou, China, examined whether circular RNAs, regulatory molecules
Hua Wang, Peiheng He, Hehai Pan, Jun long, Jianru Wang, Zemin Li, Hui Liu, Weiying Jiang, Zhaomin Zheng   +8 more
doaj   +1 more source

Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization [PDF]

, 2017
Background Recent findings demonstrated that, in mammalian cells, telomere DNA (Tel) is transcribed into telomeric repeat-containing RNA (TERRA), which is involved in fundamental biological processes, thus representing a promising anticancer target. For
Alcaro, Stefano, Artese, Anna, Costa, Giosu\ue8, Distinto, Simona, Maccioni, Elias, Moraca, Federica, Nadai, Matteo, Ortuso, Francesco, Richter, Sara, Rocca, Roberta, Scalabrin, Matteo, Talarico, Carmine   +11 more
core   +1 more source

Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs

Frontiers in Microbiology, 2021
Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa, Daniel Oh, Jerico Santos, Jerico Santos, Sarah Dremel, Guruswamy Mahesh, Thomas S. Uldrick, Robert Yarchoan, Vishal N. Kopardé, Vishal N. Kopardé, Joseph M. Ziegelbauer   +10 more
doaj   +1 more source

Circular RNAs and Cardiovascular Regeneration [PDF]

Frontiers in Cardiovascular Medicine, 2021
circular RNAs (circRNAs) are a type of non-coding RNAs that are widely present in eukaryotic cells. They have the characteristics of stable structure, high abundance, and cell or tissue specific expression. circRNAs are single-stranded RNAs that are covalently back spliced to form closed circular loops.
Ling Tang, Pengsheng Li, Michelle Jang, Wuqiang Zhu   +3 more
openaire   +3 more sources

Search for virus specific DNA sequences and viral particles in mitochondria of avian leukemic myeloblasts [PDF]

, 1977
The intracellular localization of the avian myeloblastosis virus (AMV) genome was studied. Nuclear and mitochondrial DNAs from myeloblasts were examined by hybridization with 32P labeled AMV-RNA of high molecular weight for the presence of virus specific
Oda, Takuzo, Ogura, Hajime
core   +1 more source