Protein-RNA interactions: a structural analysis [PDF]
, 2001 A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Berman, HM +4 more
core +2 more sources
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Nature, 2016 Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction. Although most genetic diseases arise from point mutations, current approaches to point mutation correction are ...
Alexis C. Komor +4 more
semanticscholar +1 more source
Two Classes of Silencing RNAs Move between Caenorhabditis elegans Tissues [PDF]
, 2013 Organism-wide RNA interference (RNAi) is due to the transport of mobile silencing RNA throughout the organism, but the identities of these mobile RNA species in animals are unknown. Here, we present genetic evidence that both the initial double-stranded
Garcia, Giancarlo +2 more
core +1 more source
Tracking Cryptosporidium parvum by Sequence Analysis of Small Double-Stranded RNA
Emerging Infectious Diseases, 2001 We sequenced a 173-nucleotide fragment of the small double-stranded viruslike RNA of Cryptosporidium parvum isolates from 23 calves and 38 humans. Sequence diversity was detected at 17 sites.
Lihua Xiao +3 more
doaj +1 more source
siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. [PDF]
PLoS ONE, 2011 RNA interference (RNAi) is a set of intracellular pathways in eukaryotes that controls both exogenous and endogenous gene expression. The power of RNAi to knock down (silence) any gene of interest by the introduction of synthetic small-interfering (si ...
John A H Hoerter +3 more
doaj +1 more source
Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4 [PDF]
, 2006 The genome of bacteriophage T4 encodes three polynucleotide ligases, which seal the backbone of nucleic acids during infection of host bacteria. The T4Dnl (T4 DNA ligase) and two RNA ligases [T4Rnl1 (T4 RNA ligase 1) and T4Rnl2] join a diverse array of ...
Amitsur +61 more
core +4 more sources
Effects of Nanoparticles on Double-Stranded RNA Stability in Corn Soil [PDF]
, 2018 Double-stranded RNA (dsRNA) can potentially be used as a pesticide because these molecules trigger an immune response called RNA interference (RNAi). If the expression of essential genes matching the dsRNA sequence are silenced, then the pest dies.
Reyanldo, Miriam +7 more
core +5 more sources
Interaction of PKR with single-stranded RNA
Scientific Reports, 2017 Although the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure.
Christopher B. Mayo, James L. Cole
doaj +1 more source
Evidence that avian reovirus σNS is an RNA chaperone: implications for genome segment assortment. [PDF]
, 2015 Reoviruses are important human, animal and plant pathogens having 10-12 segments of double-stranded genomic RNA. The mechanisms controlling the assortment and packaging of genomic segments in these viruses, remain poorly understood.
Ault, J +3 more
core +1 more source
Silencing of double-stranded ribonuclease improves oral RNAi efficacy in southern green stinkbug Nezara viridula [PDF]
, 2021 Simple summary: RNAi interference (RNAi) is a conserved mechanism found in all eukaryotes. This mechanism is initiated by the presence of double-stranded RNA in the cells and leads to the blockage of protein synthesis of a target gene.
Christiaens, Olivier +3 more
core +1 more source