Results 191 to 200 of about 22,577 (244)

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

CRISPR and Fanzor in sickle cell disease: current progress and future prospects. [PDF]

Front Genome Ed
Alhumoudi AY, Alotaibi AG, Alosaimi NF, Alshalani A, Alqahtani SM, Alsaab SM, Almutiri BJ, Albariqi MMH.   +7 more
europepmc   +1 more source

MtvS1 and MtvS2 Interact with RNA polymerase to regulate the Francisella type V-A CRISPR-Cas system. [PDF]

Nat Commun
Brodmann M, Baca CF, Chandanani J, Campbell EA, Marraffini LA.   +4 more
europepmc   +1 more source

Dynamic Operations in Macromolecular Data Storage

Angewandte Chemie, EarlyView.
With the exponential growth of digital data and the limitations of conventional silicon‐based storage and computing technologies, macromolecular data storage, the practice of encoding digital information within large, complex molecules like DNA or synthetic polymers, has emerged as a scalable and sustainable alternative to traditional digital ...
Jakub Ossowski, Oskar Affenberger, Jean‐François Lutz, Maria Nerantzaki   +3 more
wiley   +1 more source

Decoding and Overcoming Temozolomide Resistance Through CRISPR/Cas Technologies. [PDF]

Mol Diagn Ther
Marques BS, Mendes M, Alves JL, Pais A, Vitorino C.   +4 more
europepmc   +1 more source

Accessibility and Alignment of Trans‐Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein

Angewandte Chemie, EarlyView.
Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu, Wei Feng, Hongquan Zhang, X. Chris Le   +3 more
wiley   +1 more source

The CRISPR-Cas toolkit for mosquito-borne virus surveillance: detection, tracing, and discovery. [PDF]

Front Cell Infect Microbiol
Wu Y, Cai H, Wu Q, Wu J, Hu J, Huang E, Li Z, Liang S, Hu X, Dai J, Liao R.   +10 more
europepmc   +1 more source

Harnessing endogenous CRISPR-Cas9 for inducible genetic engineering of <i>Apilactobacillus kunkeei</i>. [PDF]

Appl Environ Microbiol
Iyer MS, Hagström E, Näslund K, Andersson SGE.   +3 more
europepmc   +1 more source

Beyond the Edit: Integrating CRISPR-Cas Genome Editing Into the Cereal Breeding Pipeline. [PDF]

Int J Genomics
Ali B, Hafeez A, Imin N.
europepmc   +1 more source

Compact Cas12 Systems for Multiplex Engineering of Plant Abiotic-Stress Networks. [PDF]

Adv Genet (Hoboken)
Thabet SG, Alwutayd KM, Elkelish A, Safhi FA, Dawood MFA, Alqudah AM.   +5 more
europepmc   +1 more source