Results 31 to 40 of about 573,592 (269)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Nucleoporins shape germ granule architecture and balance small RNA silencing pathways

Nature Communications
Animals use small RNA pathways, such as PIWI-interacting RNA (piRNA) and small interfering RNA (siRNA), to silence harmful genetic elements. In Caenorhabditis elegans, piRNA pathway components are organized into sub-compartments within germ granules near
Kun Shi, Ying Zhang, Zhenzhen Du, Symonne C. Liu, Ivan Leon, Xinyu Fan, Heng-Chi Lee, Donglei Zhang   +7 more
doaj   +1 more source

RNAs as Proximity-Labeling Media for Identifying Nuclear Speckle Positions Relative to the Genome

iScience, 2018
Summary: It remains challenging to identify all parts of the nuclear genome that are in proximity to nuclear speckles, due to physical separation between the nuclear speckle cores and chromatin. We hypothesized that noncoding RNAs including small nuclear
Weizhong Chen, Zhangming Yan, Simin Li, Norman Huang, Xuerui Huang, Jin Zhang, Sheng Zhong   +6 more
doaj   +1 more source

Transcriptomic Analysis of Gene Networks Regulated by U11 Small Nuclear RNA in Bladder Cancer

Frontiers in Genetics, 2021
Small nuclear RNA is a class of non-coding RNA that widely exist in the nucleus of eukaryotes. Accumulated evidences have shown that small nuclear RNAs are associated with the regulation of gene expression in various tumor types.
Zhenxing Wang, Zhenxing Wang, Zhenxing Wang, Xi Wang, Xi Wang, Yaobang Wang, Yaobang Wang, Shaomei Tang, Chao Feng, Chao Feng, Lixin Pan, Lixin Pan, Qinchen Lu, Qinchen Lu, Yuting Tao, Yuting Tao, Yuanliang Xie, Yuanliang Xie, Yuanliang Xie, Qiuyan Wang, Qiuyan Wang, Zhong Tang, Zhong Tang, Zhong Tang   +23 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Long Noncoding RNAs in Metabolic Syndrome Related Disorders

Mediators of Inflammation, 2016
Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (
Magdalena Losko, Jerzy Kotlinowski, Jolanta Jura   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk. [PDF]

PLoS ONE, 2018
Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases.
Mercedes Rubio, Mariona Bustamante, Carles Hernandez-Ferrer, Dietmar Fernandez-Orth, Lorena Pantano, Yaris Sarria, Maria Piqué-Borras, Kilian Vellve, Silvia Agramunt, Ramon Carreras, Xavier Estivill, Juan R Gonzalez, Alfredo Mayor   +12 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source