Results 41 to 50 of about 903,775 (310)

Small nuclear RNAs in the ciliateTetrahymena

Nucleic Acids Research, 1985
We have isolated and partially characterized a family of small nuclear RNAs (snRNAs) from three different species of the protozoan Tetrahymena. We find six distinct snRNAs ranging in size from 100 to 250 nucleotides. The two largest snRNAs, as well as an abundant, heterogenous group of smaller snRNAs are found in the nucleolar RNA fraction. None of the
N, Pedersen, P, Hellung-Larsen, J, Engberg   +2 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Sphingomyelin regulates the transcriptional machinery in nuclear lipid microdomains

Communications Biology
Nuclear lipid microdomains rich in sphingomyelin and cholesterol content regulate double-stranded exonuclease-resistant RNA. The study aimed to elucidate the importance of nuclear lipid microdomains in safeguarding nuclear RNA from digestion and to ...
Carmela Conte, Michela Bulfoni, Federico Fiorani, Samuela Cataldi, Nicolò Gualandi, Ornella Calderini, Mercedes Garcia-Gil, Giorgia Vesca, Rita Paroni, Michele Dei Cas, Cataldo Arcuri, Alessandra Mirarchi, Tommaso Beccari, Toshihide Kobayashi, Nario Tomishige, Paola Signorelli, Francesco Curcio, Elisabetta Albi   +17 more
doaj   +1 more source

Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila [PDF]

, 2016
The conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by RNA polymerase II in a splicing-dependent fashion; however, how TREX functions is ...
Aravin, Alexei A., Chung, Yun D., Hur, Junho K., Luo, Yicheng, Marinov, Georgi K., Moon, Sungjin, Ninova, Maria   +6 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transcriptomic Analysis of Gene Networks Regulated by U11 Small Nuclear RNA in Bladder Cancer

Frontiers in Genetics, 2021
Small nuclear RNA is a class of non-coding RNA that widely exist in the nucleus of eukaryotes. Accumulated evidences have shown that small nuclear RNAs are associated with the regulation of gene expression in various tumor types.
Zhenxing Wang, Zhenxing Wang, Zhenxing Wang, Xi Wang, Xi Wang, Yaobang Wang, Yaobang Wang, Shaomei Tang, Chao Feng, Chao Feng, Lixin Pan, Lixin Pan, Qinchen Lu, Qinchen Lu, Yuting Tao, Yuting Tao, Yuanliang Xie, Yuanliang Xie, Yuanliang Xie, Qiuyan Wang, Qiuyan Wang, Zhong Tang, Zhong Tang, Zhong Tang   +23 more
doaj   +1 more source

A new yeast poly(A) polymerase complex involved in RNA quality control [PDF]

, 2005
Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors.
Štěpánka Vaňáčová, Jeannette Wolf, Georges Martin, Diana Blank, Sabine Dettwiler, Arno Friedlein, Hanno Langen, Gérard Keith, Walter Keller, Phillip Zamore, Wahle, Minvielle-Sebastia, Zhao, Edmonds, Proudfoot, Zorio, Aravind, Holm, Martin, Preker, Martin, Martin, Bard, Read, Saitoh, Wang, Sadoff, Wang, Wang, Crittenden, Kwak, Keller, van Hoof, Kuai, Kadaba, Mitchell, O'Hara, Li, Cheng, Dreyfus, Inoue, Martin, Puig, Lingner, de la Cruz, Wang, Vijayraghavan, Anderson, Gerber, Dirheimer, Mitchell, Walowsky, Dannull, Amarasinghe, Castaño, Basavappa, Kushner, Symmons, Parker, Torchet, Fromont-Racine, Ohnacker, Dichtl, Fountoulakis, Wilm, Dirheimer, Keith, Senger, Dichtl, Christofori, Falquet, Rain   +71 more
core   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Nucleoporins shape germ granule architecture and balance small RNA silencing pathways

Nature Communications
Animals use small RNA pathways, such as PIWI-interacting RNA (piRNA) and small interfering RNA (siRNA), to silence harmful genetic elements. In Caenorhabditis elegans, piRNA pathway components are organized into sub-compartments within germ granules near
Kun Shi, Ying Zhang, Zhenzhen Du, Symonne C. Liu, Ivan Leon, Xinyu Fan, Heng-Chi Lee, Donglei Zhang   +7 more
doaj   +1 more source

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons [PDF]

, 2018
Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of several types of RNAs, and its role in the pathogenesis of ALS may involve both direct effects of
Biscarini, Silvia, Bozzoni, Irene, Caffarelli, Elisa, Capauto, Davide, Colantoni, Alessio, Laneve, Pietro, Lu, Lei, Morlando, Mariangela, Peruzzi, Giovanna, Santini, Tiziana, Shneider, Neil A.   +10 more
core   +2 more sources