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The RNA Architecture of the SARS-CoV-2 3′-Untranslated Region [PDF]

Viruses, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3′ untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication ...
Junxing Zhao, Jianming Qiu, Sadikshya Aryal, Jennifer L. Hackett, Jingxin Wang   +4 more
doaj   +4 more sources

Profiling Alternative 3′ Untranslated Regions in Sorghum using RNA-seq Data [PDF]

Frontiers in Genetics, 2020
Sorghum is an important crop widely used for food, feed, and fuel. Transcriptome-wide studies of 3′ untranslated regions (3′UTR) using regular RNA-seq remain scarce in sorghum, while transcriptomes have been characterized extensively using Illumina short-
Min Tu, Yin Li
doaj   +3 more sources

Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer

Cellular Oncology, 2007
The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis ...
Isabel López de Silanes, María Paz Quesada, Manel Esteller   +2 more
doaj   +4 more sources

The untranslated regions of classic swine fever virus RNA trigger apoptosis.

PLoS ONE, 2014
Classical swine fever virus (CSFV) causes a broad range of disease in pigs, from acute symptoms including high fever and hemorrhages, to chronic disease or unapparent infection, depending on the virus strain.
Wei-Li Hsu, Chung-Lun Chen, Shi-Wei Huang, Chia-Chen Wu, I-Hsuan Chen, Muthukumar Nadar, Yin-Peng Su, Ching-Hsiu Tsai   +7 more
doaj   +4 more sources

TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia. [PDF]

PLoS Biology
TAR DNA-binding protein 43 (TDP-43) dysfunction is a hallmark of several neurodegenerative diseases, including frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer's disease.
Vidhya Maheswari Jawahar, Yi Zeng, Ellen M Armour, Mei Yue, Kathryn Citrano, Anastasiia Lovchykova, Madison M Reeves, Bailey Rawlinson, Michael DeTure, Judith A Dunmore, Yuping Song, Sophie K Ball, Zbigniew K Wszolek, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Gregory S Day, Scott A Small, Dennis W Dickson, Michael E Ward, Tania F Gendron, Yongjie Zhang, Mercedes Prudencio, Aaron D Gitler, Leonard Petrucelli   +24 more
doaj   +2 more sources

Expression of distinct RNAs from 3′ untranslated regions [PDF]

Nucleic Acids Research, 2010
The 3' untranslated regions (3'UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of 3'UTRs in human, mouse and fly are also expressed separately from the associated protein-coding sequences to which they are normally linked, likely by post-transcriptional cleavage.
T. Mercer, D. Wilhelm, M. Dinger, G. Solda, D. Korbie, E. Glazov, V. Truong, M. Schwenke, C. Simons, K. Matthaei, R. Saint, P. Koopman, J. S. Mattick   +12 more
openaire   +3 more sources

Small Untranslated RNA Antitoxin inBacillus subtilis [PDF]

Journal of Bacteriology, 2005
ABSTRACTToxin-antitoxin (TA) modules are pairs of genes in which one member encodes a toxin that is neutralized or whose synthesis is prevented by the action of the product of the second gene, an antitoxin, which is either protein or RNA. We now report the identification of a TA module in the chromosome ofBacillus subtilisin which the antitoxin is an ...
Jessica M, Silvaggi, John B, Perkins, Richard, Losick   +2 more
openaire   +2 more sources

Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia

International Journal of Molecular Sciences, 2023
Before the advent of next-generation sequencing, research on acute myeloid leukemia (AML) mostly centered on protein-coding genes. In recent years, breakthroughs in RNA sequencing technologies and whole transcriptome analysis have led to the discovery that approximately 97.5% of the human genome is transcribed into non-coding RNAs (ncRNAs).
Yeh, Shih-Chia, Cheong, Faith J. F., Tay, Yvonne   +2 more
openaire   +2 more sources

Neuronal Untranslated BC1 RNA: Targeted Gene Elimination in Mice [PDF]

Molecular and Cellular Biology, 2003
Despite the potentially important roles of untranslated RNAs in cellular form or function, genes encoding such RNAs have until now received surprisingly little attention. One such gene encodes BC1 RNA, a small non-mRNA that is delivered to dendritic microdomains in neurons. We have now eliminated the BC1 RNA gene in mice.
Boris V, Skryabin, Valentina, Sukonina, Ursula, Jordan, Lars, Lewejohann, Norbert, Sachser, Ilham, Muslimov, Henri, Tiedge, Jürgen, Brosius   +7 more
openaire   +2 more sources

Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]

PLoS ONE, 2011
In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi, Rafael Queiroz, Diana Inchaustegui, Mark Carrington, Christine Clayton   +4 more
doaj   +1 more source