Results 1 to 10 of about 574,963 (244)
VGEA: an RNA viral assembly toolkit. [PDF]
PeerJ, 2021 Next generation sequencing (NGS)-based studies have vastly increased our understanding of viral diversity. Viral sequence data obtained from NGS experiments are a rich source of information, these data can be used to study their epidemiology, evolution, transmission patterns, and can also inform drug and vaccine design.
Oluniyi PE +13 more
europepmc +6 more sources
The direct and indirect drivers shaping RNA viral communities in grassland soils [PDF]
mSystemsRecent studies have revealed diverse RNA viral communities in soils. Yet, how environmental factors influence soil RNA viruses remains largely unknown. Here, we recovered RNA viral communities from bulk metatranscriptomes sequenced from grassland soils ...
Ruonan Wu +2 more
doaj +2 more sources
RNA modifications go viral. [PDF]
PLoS Pathogens, 2017 Nandan S Gokhale, Stacy M Horner
doaj +4 more sources
Packaging of viral RNAs in virions of adenoviruses [PDF]
Virology Journal, 2009 Earlier, we detected viral RNAs packaged in the porcine adenovirus (PAdV) -3 virions. Using Southern blot analysis, we further demonstrated that the viral RNAs were predominantly packaged in CsCl purified mature capsids (containing viral genome) than ...
Xing Li, Tikoo Suresh K
doaj +4 more sources
Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle
Microbiology Spectrum, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2 propagation is mediated by the protein interaction between viral proteins and host cells.
Trang T. X. Huynh +7 more
doaj +1 more source
A natural product YSK-A blocks SARS-CoV-2 propagation by targeting multiple host genes
Scientific Reports, 2023 Natural products and herbal medicine have been widely used in drug discovery for treating infectious diseases. Recent outbreak of COVID-19 requires various therapeutic strategies.
Thuy X. Pham +4 more
doaj +1 more source
Nature Communications, 2021 Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally ...
Veronica V. Rezelj +23 more
doaj +1 more source
Reovirus Low-Density Particles Package Cellular RNA
Viruses, 2021 Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner +3 more
doaj +1 more source
Viral RNAs Are Unusually Compact [PDF]
PLoS ONE, 2014 A majority of viruses are composed of long single-stranded genomic RNA molecules encapsulated by protein shells with diameters of just a few tens of nanometers. We examine the extent to which these viral RNAs have evolved to be physically compact molecules to facilitate encapsulation. Measurements of equal-length viral, non-viral, coding and non-coding
Gopal, Ajaykumar +6 more
openaire +6 more sources
A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity [PDF]
The EMBO Journal, 2011 Selective protein degradation via the ubiquitin-proteasome system (UPS) plays an essential role in many major cellular processes, including host-pathogen interactions. We previously reported that the tightly regulated viral RNA-dependent RNA polymerase (RdRp) of the positive-strand RNA virus Turnip yellow mosaic virus (TYMV) is degraded by the UPS in ...
Chenon, Mélanie +3 more
openaire +3 more sources