Results 1 to 10 of about 1,113,600 (301)
RNA Control of HIV-1 Particle Size Polydispersity [PDF]
PLoS ONE, 2014 HIV-1, an enveloped RNA virus, produces viral particles that are known to be much more heterogeneous in size than is typical of non-enveloped viruses. We present here a novel strategy to study HIV-1 Viral Like Particles (VLP) assembly by measuring the ...
Beck, Yvonne +9 more
core +22 more sources
The direct and indirect drivers shaping RNA viral communities in grassland soils [PDF]
mSystemsRecent studies have revealed diverse RNA viral communities in soils. Yet, how environmental factors influence soil RNA viruses remains largely unknown. Here, we recovered RNA viral communities from bulk metatranscriptomes sequenced from grassland soils ...
Ruonan Wu +2 more
doaj +2 more sources
Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle
Microbiology Spectrum, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2 propagation is mediated by the protein interaction between viral proteins and host cells.
Trang T. X. Huynh +7 more
doaj +1 more source
A natural product YSK-A blocks SARS-CoV-2 propagation by targeting multiple host genes
Scientific Reports, 2023 Natural products and herbal medicine have been widely used in drug discovery for treating infectious diseases. Recent outbreak of COVID-19 requires various therapeutic strategies.
Thuy X. Pham +4 more
doaj +1 more source
Nature Communications, 2021 Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally ...
Veronica V. Rezelj +23 more
doaj +1 more source
Reovirus Low-Density Particles Package Cellular RNA
Viruses, 2021 Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner +3 more
doaj +1 more source
Development of a minigenome cassette for Lettuce necrotic yellows virus: A first step in rescuing a plant cytorhabdovirus [PDF]
, 2020 Rhabdoviruses are enveloped negative-sense RNA viruses that have numerous biotechnological applications. However, recovering plant rhabdoviruses from cDNA remains difficult due to technical difficulties such as the need for concurrent in planta ...
Drake, P +3 more
core +1 more source
mBio, 2021 Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often ...
Ana Cristina Gonzalez-Perez +14 more
doaj +1 more source
Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion
Viruses, 2022 The hepatitis C virus (HCV) co-opts numerous cellular elements, including proteins, lipids, and microRNAs, to complete its viral life cycle. The cellular RNA-binding protein, poly(rC)-binding protein 1 (PCBP1), was previously reported to bind to the 5 ...
Sophie E. Cousineau +2 more
doaj +1 more source
A discontinuous RNA platform mediates RNA virus replication: building an integrated model for RNA-based regulation of viral processes. [PDF]
PLoS Pathogens, 2009 Plus-strand RNA viruses contain RNA elements within their genomes that mediate a variety of fundamental viral processes. The traditional view of these elements is that of local RNA structures.
Baodong Wu +5 more
doaj +1 more source