Results 1 to 10 of about 870,257 (232)
Viral RNAs Are Unusually Compact [PDF]
PLoS ONE, 2014 A majority of viruses are composed of long single-stranded genomic RNA molecules encapsulated by protein shells with diameters of just a few tens of nanometers. We examine the extent to which these viral RNAs have evolved to be physically compact molecules to facilitate encapsulation. Measurements of equal-length viral, non-viral, coding and non-coding
Gopal, Ajaykumar +6 more
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VGEA: an RNA viral assembly toolkit. [PDF]
PeerJ, 2021 Next generation sequencing (NGS)-based studies have vastly increased our understanding of viral diversity. Viral sequence data obtained from NGS experiments are a rich source of information, these data can be used to study their epidemiology, evolution, transmission patterns, and can also inform drug and vaccine design.
Oluniyi PE +13 more
europepmc +6 more sources
A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity [PDF]
The EMBO Journal, 2011 Selective protein degradation via the ubiquitin-proteasome system (UPS) plays an essential role in many major cellular processes, including host-pathogen interactions. We previously reported that the tightly regulated viral RNA-dependent RNA polymerase (RdRp) of the positive-strand RNA virus Turnip yellow mosaic virus (TYMV) is degraded by the UPS in ...
Chenon, Mélanie +3 more
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RNA Interference for Viral Infections [PDF]
Current Drug Targets, 2012 The treatment of viral infections has relied on pre-emptive vaccination or use of a limited range of anti-viral drugs. However, the majority of viruses have no available drugs and treatment is merely supportive. RNA interference (RNAi) offers the ability to directly and rapidly treat virus infections via the targeting of viral genes.
Nigel A.J. McMillan +3 more
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Viral suppression of RNA silencing [PDF]
Science China Life Sciences, 2012 يلعب إسكات الجينات (إسكات الحمض النووي الريبي) دورًا أساسيًا في الدفاع المضاد للفيروسات في النباتات والفطريات واللافقاريات. تقوم الفيروسات بتشفير البروتينات التي تمنع إسكات الجينات لمواجهة دفاع المضيف. تم تحديد المثبطات الفيروسية لإسكات الحمض النووي الريبي (RSVs) من جميع الفيروسات النباتية تقريبًا التي تولد وبعض فيروسات الحشرات والثدييات. كشفت الدراسات
Lin Jiang, Chunhong Wei, Yang Li
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Viral RNA as a Branched Polymer
, 2023 24 pages, 9 ...
Vaupotič, Domen +4 more
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Viral sensing by RNA helicases
Virologie, 2020 A key aspect of antiviral immunity is the distinction between "self" and "non-self" components. This distinction can be established through the detection of double-stranded RNA (dsRNA), a common sign of viral infection, by cytosolic RNA helicases.
Rousseau, Claire, Meignin, Carine
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Uirusu, 2009 Many lines of recent evidence indicate that non-coding RNAs including micro RNAs (miRNAs) and small interfering RNAs (siRNAs) play an important role in the control of gene expression in diverse cellular processes and in defense responses against molecular parasites such as viruses and transposons.
Hiro-oki Iwakawa, Testuro Okuno
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Regulation of PKR By Viral RNAS [PDF]
Biophysical Journal, 2010 PKR is an interferon-induced kinase that plays a key role in the innate immunity response to viral infection. Upon binding dsRNA, PKR undergoes autophosphorylation reactions that activate the kinase. We have investigated the mechanism of PKR activation by two viral RNAs that regulate PKR. HIV-I TAR is a 23 bp RNA hairpin with three bulges that is known
James L. Cole +6 more
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The Unusual Compactness of Viral RNA [PDF]
Biophysical Journal, 2012 We present complementary experimental and computational studies of the relative sizes of equal-length long single-stranded (ss) RNA molecules. Comparison of viral, non-viral, coding and non-coding RNAs of length 2117 nucleotides (nt) shows viral RNA to have among the highest gel-mobilities and smallest hydrodynamic radii in solution.
Ajaykumar Gopal +6 more
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