Results 11 to 20 of about 2,788,248 (339)
RNA Control of HIV-1 Particle Size Polydispersity [PDF]
PLoS ONE, 2014 HIV-1, an enveloped RNA virus, produces viral particles that are known to be much more heterogeneous in size than is typical of non-enveloped viruses. We present here a novel strategy to study HIV-1 Viral Like Particles (VLP) assembly by measuring the ...
Beck, Yvonne +9 more
core +21 more sources
Viral evasion of intracellular DNA and RNA sensing
Nature Reviews Microbiology, 2016 The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that are adept at evading or actively suppressing host immunity.
Ying Kai Chan, Michaela U Gack
exaly +2 more sources
Viral RNA structure-based strategies to manipulate translation
Nature Reviews Microbiology, 2018 Viruses must co-opt the cellular translation machinery to produce progeny virions. Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation apparatus, in many cases using elegant RNA-centred strategies.
Jeffrey S Kieft
exaly +2 more sources
Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle
Microbiology Spectrum, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2 propagation is mediated by the protein interaction between viral proteins and host cells.
Trang T. X. Huynh +7 more
doaj +1 more source
A natural product YSK-A blocks SARS-CoV-2 propagation by targeting multiple host genes
Scientific Reports, 2023 Natural products and herbal medicine have been widely used in drug discovery for treating infectious diseases. Recent outbreak of COVID-19 requires various therapeutic strategies.
Thuy X. Pham +4 more
doaj +1 more source
Nature Communications, 2021 Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally ...
Veronica V. Rezelj +23 more
doaj +1 more source
Reovirus Low-Density Particles Package Cellular RNA
Viruses, 2021 Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner +3 more
doaj +1 more source
A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity [PDF]
The EMBO Journal, 2011 Selective protein degradation via the ubiquitin-proteasome system (UPS) plays an essential role in many major cellular processes, including host-pathogen interactions. We previously reported that the tightly regulated viral RNA-dependent RNA polymerase (RdRp) of the positive-strand RNA virus Turnip yellow mosaic virus (TYMV) is degraded by the UPS in ...
Chenon, Mélanie +3 more
openaire +2 more sources
Development of a minigenome cassette for Lettuce necrotic yellows virus: A first step in rescuing a plant cytorhabdovirus [PDF]
, 2020 Rhabdoviruses are enveloped negative-sense RNA viruses that have numerous biotechnological applications. However, recovering plant rhabdoviruses from cDNA remains difficult due to technical difficulties such as the need for concurrent in planta ...
Drake, P +3 more
core +1 more source
mBio, 2021 Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often ...
Ana Cristina Gonzalez-Perez +14 more
doaj +1 more source