Results 21 to 30 of about 574,963 (244)

RNA Silencing and Plant Viral Diseases

Molecular Plant-Microbe Interactions, 2012
RNA silencing plays a critical role in plant resistance against viruses, with multiple silencing factors participating in antiviral defense. Both RNA and DNA viruses are targeted by the small RNA-directed RNA degradation pathway, with DNA viruses being ...
Ming-Bo Wang, Chikara Masuta, Neil A. Smith, Hanako Shimura   +3 more
doaj   +1 more source

Regulation of PKR By Viral RNAS [PDF]

Biophysical Journal, 2010
PKR is an interferon-induced kinase that plays a key role in the innate immunity response to viral infection. Upon binding dsRNA, PKR undergoes autophosphorylation reactions that activate the kinase. We have investigated the mechanism of PKR activation by two viral RNAs that regulate PKR. HIV-I TAR is a 23 bp RNA hairpin with three bulges that is known
James L. Cole, Graeme L. Conn, C. Jason Wong, Philip C. Bevilacqua, Laurie A. Heinicke, Jeffrey W. Lary, Katherine Launer-Felty   +6 more
openaire   +2 more sources

RNA Structural Elements of Hepatitis C Virus Controlling Viral RNA Translation and the Implications for Viral Pathogenesis

Viruses, 2012
Hepatitis C virus (HCV) genome multiplication requires the concerted action of the viral RNA, host factors and viral proteins. Recent studies have provided information about the requirement of specific viral RNA motifs that play an active role in the ...
Encarnación Martinez-Salas, David Piñeiro   +1 more
doaj   +1 more source

Perspectives on Viral RNA Genomes and the RNA Folding Problem

Viruses, 2020
Viral RNA genomes change shape as virus particles disassemble, form replication complexes, attach to ribosomes for translation, evade host defense mechanisms, and assemble new virus particles.
Susan J. Schroeder
doaj   +1 more source

The Unusual Compactness of Viral RNA [PDF]

Biophysical Journal, 2012
We present complementary experimental and computational studies of the relative sizes of equal-length long single-stranded (ss) RNA molecules. Comparison of viral, non-viral, coding and non-coding RNAs of length 2117 nucleotides (nt) shows viral RNA to have among the highest gel-mobilities and smallest hydrodynamic radii in solution.
Ajaykumar Gopal, Avinoam Ben-Shaul, Aron M. Yoffe, A. L. N. Rao, William M. Gelbart, Defne E. Egecioglu, Charles M. Knobler   +6 more
openaire   +2 more sources

Functional RNA Elements in the Dengue Virus Genome

Viruses, 2011
Dengue virus (DENV) genome amplification is a process that involves the viral RNA, cellular and viral proteins, and a complex architecture of cellular membranes.
Andrea V. Gamarnik, Claudia V. Filomatori, Leopoldo G. Gebhard   +2 more
doaj   +1 more source

Virus-derived DNA drives mosquito vector tolerance to arboviral infection

Nature Communications, 2016
Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of ...
Bertsy Goic, Kenneth A. Stapleford, Lionel Frangeul, Aurélien J. Doucet, Valérie Gausson, Hervé Blanc, Nidia Schemmel-Jofre, Gael Cristofari, Louis Lambrechts, Marco Vignuzzi, Maria-Carla Saleh   +10 more
doaj   +1 more source

Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral Preparations

Frontiers in Cell and Developmental Biology, 2022
Viruses package host RNAs in their virions which are associated with a range of functions in the viral life cycle. Previous transcriptomic profiling of host RNA packaging mostly focused on retroviruses.
Noah Peña, Wen Zhang, Christopher Watkins, Mateusz Halucha, Hala Alshammary, Matthew M. Hernandez, Matthew M. Hernandez, Wen-Chun Liu, Wen-Chun Liu, Randy A. Albrecht, Randy A. Albrecht, Adolfo Garcia-Sastre, Adolfo Garcia-Sastre, Adolfo Garcia-Sastre, Adolfo Garcia-Sastre, Viviana Simon, Viviana Simon, Viviana Simon, Viviana Simon, Christopher Katanski, Tao Pan, Tao Pan   +21 more
doaj   +1 more source

Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism. [PDF]

PLoS ONE, 2013
RNA helicase A (RHA) promotes multiple steps in HIV-1 production including transcription and translation of viral RNA, annealing of primer tRNA(Lys3) to viral RNA, and elevating the ratio of unspliced to spliced viral RNA.
Li Xing, Meijuan Niu, Xia Zhao, Lawrence Kleiman   +3 more
doaj   +1 more source

Staufen1 Protein Participates Positively in the Viral RNA Replication of Enterovirus 71

Viruses, 2019
The double-stranded RNA-binding protein Staufen1 (Stau1) has multiple functions during RNA virus infection. In this study, we investigated the role of Stau1 in viral translation by using a combination of enterovirus 71 (EV-A71) infection, RNA reporter ...
Young-Mao Chen, Bo-Ting Ou, Chao-Ying Chen, Han-Hsiang Chan, Chih-Jung Chen, Robert YL Wang   +5 more
doaj   +1 more source