Results 31 to 40 of about 574,963 (244)
Critical Care, 2020 Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.
Jesús F. Bermejo-Martin +65 more
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Viruses, 2020 Group-B enteroviruses (EV-B) are ubiquitous naked single-stranded positive RNA viral pathogens that are responsible for common acute or persistent human infections.
Marie Glenet +7 more
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Two herpesviral noncoding PAN RNAs are functionally homologous but do not associate with common chromatin loci. [PDF]
PLoS Pathogens, 2018 During lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV), a nuclear viral long noncoding RNA known as PAN RNA becomes the most abundant polyadenylated transcript in the cell. Knockout or knockdown of KSHV PAN RNA results in loss of late
Johanna B Withers +4 more
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RNA Structures and Their Role in Selective Genome Packaging
Viruses, 2021 To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye +7 more
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A comparison of viral RNA-dependent RNA polymerases
Current Opinion in Structural Biology, 2006 Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg, to initiate RNA replication. The recent explosion of structural information on picornaviral 3D polymerases has provided insights into the initiation of RNA synthesis and chain ...
Ferrer-Orta, Cristina +3 more
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All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes
Frontiers in Immunology, 2020 Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication.
Emily Yang +3 more
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mBio, 2021 The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and ...
Xueyan Zhang +9 more
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Nucleocapsid-Independent Specific Viral RNA Packaging via Viral Envelope Protein and Viral RNA Signal [PDF]
Journal of Virology, 2003 ABSTRACT For any of the enveloped RNA viruses studied to date, recognition of a specific RNA packaging signal by the virus's nucleocapsid (N) protein is the first step described in the process of viral RNA packaging. In the murine coronavirus a selective interaction between the viral transmembrane envelope protein M and the viral
Narayanan, K +3 more
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Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding
Cell Discovery, 2022 Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg ...
Xiaohua Tang +31 more
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Chemistry & Biology, 1997 Viruses can express intron-containing and intronless mRNAs, which are exported by alternative pathways. The study of the nuclear export of these unconventional mRNAs can provide key insights into the normal process of nuclear export and the alternative pathways provide an attractive target for the development of specific antiviral therapies.
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