Results 51 to 60 of about 2,788,248 (339)

Genome organization and interaction with capsid protein in a multipartite RNA virus. [PDF]

, 2020
We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV).
Beren, Christian, Chakravarty, Antara, Cui, Yanxiang, Gelbart, William M, Knobler, Charles M, Rao, ALN, Yang, Xue, Zhou, Z Hong   +7 more
core  

Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity. [PDF]

, 2007
BACKGROUND: Retroviruses selectively encapsidate two copies of their genomic RNA, the Gag protein binding a specific RNA motif in the 5' UTR of the genome.
Andrew ML Lever (60785), Anne L'Hernault (60782), Jane S Greatorex (60783), R Anthony Crowther (60784)   +3 more
core   +3 more sources

Factors associated with prolonged viral RNA shedding in patients with COVID-19

Clinical Infectious Diseases, 2020
Background An outbreak of coronavirus disease 2019 (COVID-19) is becoming a public health emergency. Data are limited on the duration and host factors related to viral shedding.
Kaijin Xu, Yanfei Chen, Jing Yuan, Ping Yi, Cheng Ding, Wen-rui Wu, Yongtao Li, Qin Ni, Rongrong Zou, Xiaohe Li, Min Xu, Ying Zhang, Hong Zhao, Xuan Zhang, Liang Yu, Jun-wei Su, Guan-jing Lang, Jun Liu, Xiaoxin Wu, Yong-zheng Guo, Jingjing Tao, D. Shi, Ling Yu, Qing Cao, B. Ruan, Lei Liu, Zhaoqin Wang, Yan Xu, Yingxia Liu, J. Sheng, Lanjuan Li   +30 more
semanticscholar   +1 more source

Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism. [PDF]

PLoS ONE, 2013
RNA helicase A (RHA) promotes multiple steps in HIV-1 production including transcription and translation of viral RNA, annealing of primer tRNA(Lys3) to viral RNA, and elevating the ratio of unspliced to spliced viral RNA.
Li Xing, Meijuan Niu, Xia Zhao, Lawrence Kleiman   +3 more
doaj   +1 more source

Force for ancient and recent life: viral and stem-loop RNA consortia promote life. [PDF]

, 2014
Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al.
Villarreal, Luis P
core   +1 more source

Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication

Journal of Experimental Medicine, 2016
Khan et al. demonstrate that the lower female reproductive tract is exceptionally vulnerable to infection by LCMV and Zika virus, as intravaginal exposure to these RNA viral pathogens elicits a dampened antiviral immune response.
Shahzada Khan, Erik M. Woodruff, M. Trapecar, Krystal A. Fontaine, Ashley Ezaki, Timothy C. Borbet, M. Ott, Shomyseh Sanjabi   +7 more
semanticscholar   +1 more source

Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity

Emerging Microbes and Infections, 2020
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab.
Weilie Chen, Y. Lan, Xiao-zhen Yuan, Xilong Deng, Yueping Li, Xiaoli Cai, Liya Li, Ruiying He, Yizhou Tan, Xizi Deng, Ming Gao, Guo-fang Tang, Ling-Zhai Zhao, Jinlin Wang, Qinghong Fan, C. Wen, Yuwei Tong, Yang-bo Tang, F. Hu, Feng Li, Xiaoping Tang   +20 more
semanticscholar   +1 more source

Nucleocapsid-Independent Specific Viral RNA Packaging via Viral Envelope Protein and Viral RNA Signal [PDF]

Journal of Virology, 2003
ABSTRACT For any of the enveloped RNA viruses studied to date, recognition of a specific RNA packaging signal by the virus's nucleocapsid (N) protein is the first step described in the process of viral RNA packaging. In the murine coronavirus a selective interaction between the viral transmembrane envelope protein M and the viral
Narayanan, K, Chen, CJ, Maeda, J, Makino, S   +3 more
openaire   +2 more sources

RNA Structures and Their Role in Selective Genome Packaging

Viruses, 2021
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth   +7 more
doaj   +1 more source

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Nature Communications, 2020
The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics.
A. Shannon, B. Selisko, N. Le, Johanna Huchting, F. Touret, G. Piorkowski, Véronique Fattorini, F. Ferron, E. Decroly, C. Meier, B. Coutard, O. Peersen, B. Canard   +12 more
semanticscholar   +1 more source