Results 11 to 20 of about 2,365,116 (344)

Data of protein-RNA binding sites

Data in Brief, 2017
Despite the increasing number of protein-RNA complexes in structure databases, few data resources have been made available which can be readily used in developing or testing a method for predicting either protein-binding sites in RNA sequences or RNA ...
Wook Lee, Byungkyu Park, Daesik Choi, Kyungsook Han   +3 more
doaj   +4 more sources

Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding

Computational and Structural Biotechnology Journal, 2020
The oxidation of RNA has been implicated in the development of many diseases. Among the four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the formation of 8-oxo-7,8-dihydroguanosine (8-oxoG). Despite the limited knowledge
Juan C. Gonzalez-Rivera, Asuka A. Orr, Sean M. Engels, Joseph M. Jakubowski, Mark W. Sherman, Katherine N. O'Connor, Tomas Matteson, Brendan C. Woodcock, Lydia M. Contreras, Phanourios Tamamis   +9 more
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An in vitro technique to identify the RNA binding-site sequences for RNA-binding proteins [PDF]

BioTechniques, 2017
RNA–protein interactions play a major role in gene regulation. Although many techniques to analyze RNA–protein interactions have been developed, noteworthy challenges such as determining the RNA sequences that bind RNA-binding proteins (RBPs) remain ...
SunKyung Choi, Chungoo Park, Kyoon Eon Kim, Kee K. Kim   +3 more
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RNA binding proteins in osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder. Its progression is characterized by aberrant expression of genes involved in inflammation, proliferation, and metabolism of chondrocytes ...
Qian Yi, Qian Yi, Qian Yi, Zhenhan Deng, Jiaji Yue, Jinglong He, Jianyi Xiong, Wei Sun, Weichao Sun, Weichao Sun   +9 more
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RNA-binding proteins [PDF]

WormBook, 2006
The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse genetics. They tend to display tissue-specific mutant phenotypes, which underscore their functional
Lee, Min'Ho, Schedl, Tim
openaire   +4 more sources

RNA-binding proteins in bacteria [PDF]

Nature Reviews Microbiology, 2018
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA-protein interactions.
Erik Holmqvist, Jörg Vogel
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RNA-Binding Proteins in Acute Leukemias [PDF]

International Journal of Molecular Sciences, 2020
Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate ...
Konstantin Schuschel, Matthias Helwig, Stefan Hüttelmaier, Dirk Heckl, Jan-Henning Klusmann, Jessica I Hoell   +5 more
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Chemoproteomic capture of RNA binding activity in living cells

Nature Communications, 2023
Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition and function in cells.
Andrew J. Heindel, Jeffrey W. Brulet, Xiantao Wang, Michael W. Founds, Adam H. Libby, Dina L. Bai, Michael C. Lemke, David M. Leace, Thurl E. Harris, Markus Hafner, Ku-Lung Hsu   +10 more
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Identification of RNA-binding Proteins [PDF]

BIO-PROTOCOL, 2016
This protocol describes the extraction of RNA-binding proteins (RBPs) from cell lysates. In order to pull down target RBPs, 5-bromo-UTP (BrUTP)-incorporated RNA probes are used, which are generated by in vitro transcription. The schematic diagram (Flowchart) with procedure is indicated (Figure1 and Figure 2).Figure 1.
Kazuya Masuda, Tadamitsu Kishimoto
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Possible Involvement of the Phloem Lectin in Long-Distance Viroid Movement

Molecular Plant-Microbe Interactions, 2001
Incubation with cucumber phloem exudate in vitro results in a dramatic decrease in the electrophoretic mobility of Hop stunt viroid. UV cross-linking and a combination of size exclusion and ion exchange chromatography indicate that this phenomenon ...
R. A. Owens, M. Blackburn, B. Ding
doaj   +1 more source