Results 51 to 60 of about 2,365,116 (344)
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Structural basis for specific RNA recognition by the alternative splicing factor RBM5
Nature Communications, 2023 The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of genes important for apoptosis and cell proliferation and have been implicated in cancer. RBM5 harbors structural modules for
Komal Soni +8 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Type I IFN signaling is maintained under homeostatic conditions, which plays a crucial role in antiviral immunity. Epigenetic regulation of innate immunity and inflammation attracts much attention now. However, the underlying mechanisms need
Yuan Zhang +6 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
RNA-binding proteins in Mendelian disease
Trends in Genetics, 2013 RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating over 1100 proteins in RNA binding.
Castello, Alfredo +3 more
openaire +4 more sources
Non-Coding RNA, 2023 Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically generated
Yuka Ikeda +8 more
doaj +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
RNA‐binding proteins in diabetic microangiopathy
Journal of Clinical Laboratory Analysis, 2022 AbstractBackgroundAs the most common complication of diabetes, the diabetic microangiopathy characterizes diabetic retinopathy (DR) and nephropathy (DN). Diabetic microangiopathy has always been a serious clinical problem. A wide variety of nucleic acid interacting factors called the RNA binding proteins (RBPS) take part in several crucial cellular ...
Chao Tu, Liangzhi Wang, Lan Wei
openaire +2 more sources
Bio-Protocol, 2021 RNA-protein interactions are often mediated by dedicated canonical RNA binding domains. However, interactions through non-canonical domains with unknown specificity are increasingly observed, raising the question how RNA targets are recognized. Knowledge
Marisa Müller +2 more
doaj +1 more source
LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR
Nucleic Acids Research, 2016 The function of the vast majority of mammalian long noncoding (lnc) RNAs remains unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as cyrano in zebrafish, revealed that OIP5-AS1 reduces cell proliferation.
Jiyoung Kim +6 more
semanticscholar +1 more source