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RNA-Binding Proteins in Cardiomyopathies [PDF]
Journal of Cardiovascular Development and DiseaseThe post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential ...
De-Li Shi
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RNA-binding proteins in bone pathophysiology [PDF]
Frontiers in Cell and Developmental BiologyBone remodelling is a highly regulated process that maintains mineral homeostasis and preserves bone integrity. During this process, intricate communication among all bone cells is required.
Paola Maroni +3 more
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RNA binding proteins in osteoarthritis
Frontiers in Cell and Developmental Biology, 2022 Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder.
Qian Yi +9 more
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Guardian of Genetic Messenger-RNA-Binding Proteins [PDF]
Biomolecules, 2016 RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express
Antje Anji, Meena Kumari
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The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid. [PDF]
PLoS Pathogens, 2016 The APOBEC3 (A3) cytidine deaminases are antiretroviral proteins, whose targets include human immunodeficiency virus type-1 (HIV-1). Their incorporation into viral particles is critical for antiviral activity and is driven by interactions with the RNA ...
Ashley York +3 more
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RNA-binding proteins as versatile metabolic regulators [PDF]
npj Metabolic Health and DiseaseMetabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells.
Ellie Koletsou, Ina Huppertz
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The role of disorder in RNA binding affinity and specificity [PDF]
Open Biology, 2020 Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins typically attain the physiological specificity and affinity for their RNA targets by combining several RNA-binding modules.
Diana S. M. Ottoz, Luke E. Berchowitz
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RNA binding proteins in MLL-rearranged leukemia
Experimental Hematology & Oncology, 2022 RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease.
Tiffany M. Tran, Dinesh S. Rao
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Frontiers in Molecular Neuroscience, 2021 Core spliceosome and related RNA-binding proteins aggregate in Alzheimer’s disease (AD) brain even in early asymptomatic stages (AsymAD) of disease.
Qi Guo +15 more
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The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
eLife, 2021 TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains has ...
Juan Carlos Rengifo-Gonzalez +8 more
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