Results 21 to 30 of about 2,650,407 (299)

Classifying RNA-binding proteins based on electrostatic properties. [PDF]

PLoS Computational Biology, 2008
Protein structure can provide new insight into the biological function of a protein and can enable the design of better experiments to learn its biological roles.
Shula Shazman, Yael Mandel-Gutfreund
doaj   +1 more source

RNA-binding proteins contribute to small RNA loading in plant extracellular vesicles

Nature Plants, 2021
Plants use extracellular vesicles (EVs) to transport small RNAs (sRNAs) into their fungal pathogens and silence fungal virulence-related genes through a phenomenon called ‘cross-kingdom RNAi’. It remains unknown, however, how sRNAs are selectively loaded
Baoye He, Qiang Cai, Lulu Qiao, Chien-Yu Huang, Shumei Wang, Weili Miao, Tommy Ha, Yinsheng Wang, Hailing Jin   +8 more
semanticscholar   +1 more source

A large-scale binding and functional map of human RNA-binding proteins

Nature, 2020
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome1. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the ...
Eric L. Van Nostrand, Peter Freese, G. Pratt, Xiaofeng Wang, Xintao Wei, Rui Xiao, S. Blue, Daniel Dominguez, Neal A. L. Cody, S. Olson, B. Sundararaman, L. Zhan, C. Bazile, Louis Philip Benoit Bouvrette, Jia-Yu Chen, Michael O. Duff, Keri E. Garcia, C. Gelboin-Burkhart, Abigail Hochman, Nicole J. Lambert, Hai-Ri Li, Thai Nguyen, T. Palden, Ines Rabano, S. Sathe, Rebecca Stanton, Julie Bergalet, Bing Zhou, Amanda Su, Ruth Wang, Brian A. Yee, Ashley L. Louie, S. Aigner, Xiang-Dong Fu, E. Lécuyer, C. Burge, Brenton R. Graveley, Gene W. Yeo   +37 more
semanticscholar   +1 more source

Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2021
Core spliceosome and related RNA-binding proteins aggregate in Alzheimer’s disease (AD) brain even in early asymptomatic stages (AsymAD) of disease.
Qi Guo, Eric B. Dammer, Eric B. Dammer, Maotian Zhou, Sean R. Kundinger, Marla Gearing, Marla Gearing, James J. Lah, James J. Lah, Allan I. Levey, Allan I. Levey, Joshua M. Shulman, Joshua M. Shulman, Nicholas T. Seyfried, Nicholas T. Seyfried, Nicholas T. Seyfried   +15 more
doaj   +1 more source

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions

bioRxiv, 2022
Macromolecular phase separation is thought to be one of the processes that drives the formation of membraneless biomolecular condensates in cells. The dynamics of phase separation, especially at low endogenous concentrations found in cells, are thought ...
Mrityunjoy Kar, Furqan Dar, Timothy J. Welsh, L. Vogel, R. Kühnemuth, Anupa Majumdar, G. Krainer, Titus M. Franzmann, S. Alberti, C. Seidel, T. Knowles, A. Hyman, R. Pappu   +12 more
semanticscholar   +1 more source

Robust single-cell discovery of RNA targets of RNA binding proteins and ribosomes

Nature Methods, 2021
RNA-binding proteins (RBPs) are critical regulators of gene expression and RNA processing that are required for gene function. Yet the dynamics of RBP regulation in single cells is unknown.
Kristopher W Brannan, I. Chaim, Ryan J. Marina, Brian A. Yee, Eric Kofman, Daniel A. Lorenz, Pratibha Jagannatha, Kevin D. Dong, Assael A. Madrigal, J. Underwood, Gene W. Yeo   +10 more
semanticscholar   +1 more source

RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific

Scientific Reports, 2023
Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)—proteins that associate with RNA but lack known RNA-binding domains (RBDs).
Debashish Ray, Kaitlin U. Laverty, Arttu Jolma, Kate Nie, Reuben Samson, Sara E. Pour, Cyrus L. Tam, Niklas von Krosigk, Syed Nabeel-Shah, Mihai Albu, Hong Zheng, Gabrielle Perron, Hyunmin Lee, Hamed Najafabadi, Benjamin Blencowe, Jack Greenblatt, Quaid Morris, Timothy R. Hughes   +17 more
doaj   +1 more source

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

Molecular Cell, 2017
Uwe Plessmann, , Henning Urlaub
exaly   +2 more sources

How RNA binding proteins interact with RNA: molecules and mechanisms

Molecules and Cells, 2020
SUMMARY RNA binding proteins (RBPs) comprise a large class of over 2000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse.
M. Corley, Margaret C Burns, Gene W. Yeo
semanticscholar   +1 more source

Survey of the binding preferences of RNA-binding proteins to RNA editing events

Genome Biology, 2022
Background Adenosine-to-inosine (A-to-I) editing is an important RNA posttranscriptional process related to a multitude of cellular and molecular activities.
Xiaolin Hu, Qin Zou, Li Yao, Xuerui Yang
doaj   +1 more source