Results 21 to 30 of about 465,221 (120)
Cotranscriptional kinetic folding of RNA secondary structures including pseudoknots [PDF]
Journal of Computational Biology, 2021, 2020 Computational prediction of RNA structures is an important problem in computational structural biology. Studies of RNA structure formation often assume that the process starts from a fully synthesized sequence. Experimental evidence, however, has shown that RNA folds concurrently with its elongation.
arxiv +1 more source
RNA-dependent RNA Polymerase Assay for Hepatitis E Virus
Bio-Protocol, 2017 RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome.
Vidya Nair +3 more
doaj +1 more source
Stochastic resetting in backtrack recovery by RNA polymerases [PDF]
Phys. Rev. E 93, 062411 (2016), 2016 Transcription is a key process in gene expression, in which RNA polymerases produce a complementary RNA copy from a DNA template. RNA polymerization is frequently interrupted by backtracking, a process in which polymerases perform a random walk along the DNA template.
arxiv +1 more source
Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase
Nature Communications, 2017 Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPĪ² prophage ofBacillus subtilis, which shares homology to multi-
David Forrest +3 more
doaj +1 more source
Frontiers in Genetics, 2020 BackgroundRNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral ...
Shuang Ao +8 more
doaj +1 more source
In vitro RNA-dependent RNA Polymerase Assay Using Arabidopsis RDR6
Bio-Protocol, 2018 RNA-dependent RNA polymerases (RdRPs) in eukaryotes convert single-stranded RNAs into double-stranded RNAs, thereby amplifying small interfering RNAs that play crucial roles in the regulation of development, maintenance of genome integrity and antiviral ...
Kyungmin Baeg +2 more
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Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes
Molecules, 2021 The work is devoted to the study of the complementarity of the electronic structures of the ligands and SARS-CoV-2 RNA-dependent RNA polymerase. The research methodology was based on determining of 3D maps of electron densities of complexes using an ...
Nadezhda Palko +2 more
doaj +1 more source
Mechanical Properties of Transcription [PDF]
Phys. Rev. Lett. 118, 268101 (2017), 2016 Recently the physical characterization of a number of biological processes has proven indispensable for a full understanding of natural phenomena. One such example is the mechanical properties of transcription, which have been shown to have significant effects in gene expression.
arxiv +1 more source
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
Nature Communications, 2017 The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the ...
Andre S. Godoy +6 more
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Uncovering the effect of RNA polymerase steric interactions on gene expression noise: analytical distributions of nascent and mature RNA numbers [PDF]
arXiv, 2023 The telegraph model is the standard model of stochastic gene expression, which can be solved exactly to obtain the distribution of mature RNA numbers per cell. A modification of this model also leads to an analytical distribution of the nascent RNA numbers. These solutions are routinely used for the analysis of single-cell data, including the inference
arxiv