Results 131 to 140 of about 54,796 (163)
Some of the next articles are maybe not open access.
Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors.
European Journal of Medicinal Chemistry, 2021Over recent years, many outbreaks caused by (re)emerging RNA viruses have been reported worldwide, including life-threatening Flaviviruses, such as Dengue (DENV) and Zika (ZIKV). Currently, there is only one licensed vaccine against Dengue, Dengvaxia®. However, its administration is not recommended for children under nine years.
I. Nascimento +4 more
semanticscholar +3 more sources
Journal of Cellular Biochemistry, 2018
Persistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease.
L. Ravichandran +2 more
semanticscholar +3 more sources
Persistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease.
L. Ravichandran +2 more
semanticscholar +3 more sources
Journal of Biomolecular Structure and Dynamics, 2021
In this study, we propose our novel benzophenone–coumarin derivatives (BCDs) as potent inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 virus, one of the key targets that are involved in the viral genome replication. We aim to evaluate
Shashank M. Patil +6 more
semanticscholar +1 more source
In this study, we propose our novel benzophenone–coumarin derivatives (BCDs) as potent inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 virus, one of the key targets that are involved in the viral genome replication. We aim to evaluate
Shashank M. Patil +6 more
semanticscholar +1 more source
Journal of Physical Chemistry B, 2020
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious global health issue. Remdesivir is the first antiviral compound approved by the US FDA for the SARS-CoV-2 treatment for emergency use, targeting RNA-dependent RNA ...
Padmaja D. Wakchaure +2 more
semanticscholar +1 more source
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious global health issue. Remdesivir is the first antiviral compound approved by the US FDA for the SARS-CoV-2 treatment for emergency use, targeting RNA-dependent RNA ...
Padmaja D. Wakchaure +2 more
semanticscholar +1 more source
Potential use of RNA-dependent RNA polymerase (RdRp) inhibitor against COVID-19 infection
2020Favipiravir, an inhibitor of RNA-dependent RNA polymerase used against the Japanese flu, was recently suggested as a potential COVID-19 inhibitor. Since Favipiravir targets a critical and a viral specific process, using it as a treatment could be beneficial in slowing the outbreak.
Santerre, Maryline +3 more
openaire +1 more source
Biochemistry & Physiology: Open Access, 2015
Nipah virus is an emerging zoonotic paramyxovirus that is responsible for severe outbreaks in humans and livestocks. This negative stranded RNA virus carries RNA-dependent RNA polymerase (RdRp) complex which is required for viral RNA replication and transcription as a catalytic subunit of viral replicase.
Md. Jahangir Alam +2 more
openaire +1 more source
Nipah virus is an emerging zoonotic paramyxovirus that is responsible for severe outbreaks in humans and livestocks. This negative stranded RNA virus carries RNA-dependent RNA polymerase (RdRp) complex which is required for viral RNA replication and transcription as a catalytic subunit of viral replicase.
Md. Jahangir Alam +2 more
openaire +1 more source
Conserved amino acids in HCoV-HKU1 and SARS-Cov2 at RNA-dependent RNA polymerase (RdRp) motifs
2021A novel and related to severe acute respiratory syndrome associated coronavirus (SARS-CoV2) has been identified as an infectious coronavirus originating from a Wuhan seafood market and rapidly spreading into and beyond China. While non-conserved regions of viral genome can lead to novel coronavirus subtypes, conserved regions are also very important ...
ATASEVER ARSLAN, Belkis +4 more
openaire +1 more source
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
Current Medicinal Chemistry, 2022openaire +2 more sources