Results 61 to 70 of about 22,843 (140)

Studi In Silico Senyawa Flavonoid dalam Mengambat RNA-dependent RNA polymerase (RdRp) sebagai Antivirus COVID-19

Journal of Islamic Pharmacy, 2023
Pada akhir tahun 2019, muncul coronavirus disease 2019 (COVID-19) yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yang menjadi ancaman serius bagi kesehatan masyarakat global sampai saat ini. Seiring berjalannya waktu, pengembangan obat repurposing telah menjadi metode yang efektif.
Muslikh, Faisal Akhmal, Pratama, Rizki Rahmadi, Ma'arif, Burhan, Purwitasari, Neny   +3 more
openaire   +1 more source

The structure of a dimeric form of SARS-CoV-2 polymerase

Communications Biology, 2021
Jochheim et al report an alternative, dimeric form of the coronavirus SARS-CoV-2 RNA dependent RNA polymerase (RdRp), which is used to replicate and transcribe its genome.
Florian A. Jochheim, Dimitry Tegunov, Hauke S. Hillen, Jana Schmitzová, Goran Kokic, Christian Dienemann, Patrick Cramer   +6 more
doaj   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source

Tobamoviruses CP Proteins Hijack Light‐Induced Protein (NbLIP1) to Promote Viral Replication by Facilitating VRO Formation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood.
Haoyu Chen, Mingjie Wu, Xiao Guo, Hongmei Xu, Chenwei Feng, Duxuan Liu, Jing Hua, Yanhong Hua, Zhen He, Peter Moffett, Kun Zhang   +10 more
wiley   +1 more source

Spatial Perturbations within an RNA Promoter Specifically Recognized by a Viral RNA-Dependent RNA Polymerase (RdRp) Reveal That RdRp Can Adjust Its Promoter Binding Sites [PDF]

Journal of Virology, 1999
ABSTRACT RNA synthesis during viral replication requires specific recognition of RNA promoters by the viral RNA-dependent RNA polymerase (RdRp). Four nucleotides (−17, −14, −13, and −11) within the brome mosaic virus (BMV) subgenomic core promoter are required for RNA synthesis by the BMV RdRp (R. W. Siegel et al., Proc. Natl. Acad. Sci.
S S, Stawicki, C C, Kao
openaire   +2 more sources

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases

BMC Bioinformatics, 2005
Background The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs.
Dutartre Hélène, Bussetta Cécile, Ferron François, Canard Bruno   +3 more
doaj   +1 more source

Architecture of a SARS-CoV-2 mini replication and transcription complex

Nature Communications, 2020
SARS-CoV-2 virus replication and transcription is mediated by the replication and transcription complex (RTC) that is composed of 16 non-structural proteins (nsp). Here, the authors present the cryo-EM structure of a SARS-CoV-2 mini RTC consisting of the
Liming Yan, Ying Zhang, Ji Ge, Litao Zheng, Yan Gao, Tao Wang, Zhihui Jia, Haofeng Wang, Yucen Huang, Mingyu Li, Quan Wang, Zihe Rao, Zhiyong Lou   +12 more
doaj   +1 more source

Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase

iScience, 2020
Summary: COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is currently being treated using Remdesivir, a nucleoside analog that inhibits the RNA-dependent-RNA polymerase (RdRp).
Tyler L. Dangerfield, Nathan Z. Huang, Kenneth A. Johnson   +2 more
doaj   +1 more source