Results 81 to 90 of about 22,843 (140)
Homology Modeling and Analysis of Structure Predictions of the Bovine Rhinitis B Virus RNA Dependent RNA Polymerase (RdRp) [PDF]
Bovine Rhinitis B Virus (BRBV) is a picornavirus responsible for mild respiratory infection of cattle. It is probably the least characterized among the aphthoviruses. BRBV is the closest relative known to Foot and Mouth Disease virus (FMDV) with a ~43% identical polyprotein sequence and as much as 67% identical sequence for the RNA dependent RNA ...
Rai, Devendra K., Rieder, Elizabeth
openaire +2 more sources
Bioinformatic prediction of polymerase elements in the rotavirus VP1 protein
Rotaviruses are the major cause of acute gastroenteritis in infants world-wide. The genome consists of eleven double stranded RNA segments. The major segment encodes the structural protein VP1, the viral RNA-dependent RNA polymerase (RdRp), which is a ...
RODRIGO VÁSQUEZ-DEL CARPIÓ +4 more
doaj
ABSTRACT Since its discovery, RNA interference (RNAi, also known as gene silencing) has been a key tool to downregulate gene expression in plants for a range of applications, including protection against viruses. Many of these applications require the silencing of multiple genes concomitantly.
Marie‐Emilie A. Gauthier +5 more
wiley +1 more source
Insight into Influenza: A Virus Cap-Snatching
The influenza A virus (IAV) genome consists of eight single-stranded RNA segments. Each segment is associated with a protein complex, with the 3′ and 5′ ends bound to the RNA-dependent RNA polymerase (RdRp) and the remainder associated with ...
Corey De Vlugt +2 more
doaj +1 more source
Spectroscopic ellipsometry in the Kretschmann‐Raether configuration (KRSE) is employed to characterize a DNA‐functionalized platform for viral sequence recognition. By merging SE with surface plasmon resonance, KRSE outperforms conventional SE, achieving nanomolar targeting through resonance wavelength shifts (δλ) measurements. Its enhanced interfacial
Silvia Maria Cristina Rotondi +4 more
wiley +1 more source
SARS‐CoV‐2 Chronic Intervillositis: Variations of Maternal Antiviral Response
ABSTRACT Problem Placental compromise is a determining factor in the outcome of pregnancies complicated by maternal SARS‐CoV‐2 infection. Chronic histiocytic intervillositis (CHI) is the initial response to SARS‐CoV‐2 infection, but the underlying mechanisms are poorly understood.
Daria Kozlova +8 more
wiley +1 more source
Pharmacological pitfalls and challenges in drug repurposing for emerging pathogens: lessons from COVID‐19. ABSTRACT The Covid‐19 pandemic highlighted the urgent need for effective therapies against emerging pathogens. Drug repurposing, defined as the use of existing medications for new therapeutic purposes, was extensively pursued for SARS‐CoV‐2 but ...
Inès Ben Ghezala +5 more
wiley +1 more source
Sequence Analysis of Hot Spot Regions of Spike and RNA-dependent-RNA polymerase (RdRp) Genes of SARS-CoV-2 in Kerman, Iran. [PDF]
Arefinia N +3 more
europepmc +2 more sources
Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses
One paradigm to explain the complexity of viral RNA populations is that the low fidelity of the RNA-dependent RNA polymerase (RdRp) drives high mutation rates and consequently genetic diversity.
Natalie D. Collins +5 more
doaj +1 more source

