Results 71 to 80 of about 3,148,619 (314)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Base-specific spin-labeling of RNA for structure determination [PDF]

, 2007
To facilitate the measurement of intramolecular distances in solvated RNA systems, a combination of spin-labeling, electron paramagnetic resonance (EPR), and molecular dynamics (MD) simulation is presented. The fairly rigid spin label 2,2,5,5-tetramethyl-
Olav Schiemann, Mu, Yuguang, Prisner, Thomas F., Stock, G., Engels, J.W., Prisner, TF., Thomas F. Prisner, Engels, Joachim W. (Prof. Dr.), Stock, Gerhard, Piton, N., Schiemann, Olav, Gerhard Stock, Nelly Piton, Piton, Nelly, Mu, Y., Yuguang Mu, Joachim W. Engels   +16 more
core   +1 more source

Clinical Application of the Mycobacterium tuberculosis-RNA Assay of Pericardial Tissue Specimens in the Diagnosis of Tuberculous Pericarditis

Infection and Drug Resistance, 2023
Jinjuan Zhang,1 Caifang Bu,1 Liwei Yao,1,* Kan Xu2,* 1Department of Nursing, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Zhejiang Tuberculosis Diagnosis and ...
Zhang J, Bu C, Yao L, Xu K
doaj  

Studying PR2 and PAL genes involvement in rice resistance against Acidovorax avenae subsp. Avenae [PDF]

مجله بیوتکنولوژی کشاورزی, 2016
Plant diseases are one of the major constraints of agricultural productions. Rice bacterial brown stripe, caused by Acidovorax avenae subsp. avenae is recognized by producing water-soaked and brown stripes on leaves and sheaths of rice seedlings in ...
Amir Masoud Heydari Nezhad, Vali Allah Baba zad, Heshmat Allah Rahimian   +2 more
doaj   +1 more source

Nanostructured RNA for RNA Intereference

YAKUGAKU ZASSHI, 2013
RNA interference (RNAi) is a potent and highly specific gene-silencing phenomenon which is initiated or triggered by double-stranded RNAs (dsRNAs). Shortly after the development of RNAi, small interfering RNAs (siRNAs) that are 21 nucleotides in length with a 3' nucleotide overhang were shown to be very effective in mammalian cells.
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes

Antibiotics, 2020
Aminoglycosides represent a large group of antibiotics well known for their ability to target the bacterial ribosome. In studying 6”-substituted variants of the aminoglycoside tobramycin, we serendipitously found that compounds with C12 or C14 ...
Lanqing Ying, Hongkun Zhu, Marina Y. Fosso, Sylvie Garneau-Tsodikova, Kurt Fredrick   +4 more
doaj   +1 more source

RAID: a comprehensive resource for human RNA-associated (RNA–RNA/RNA–protein) interaction [PDF]

RNA, 2014
Transcriptomic analyses have revealed an unexpected complexity in the eukaryote transcriptome, which includes not only protein-coding transcripts but also an expanding catalog of noncoding RNAs (ncRNAs). Diverse coding and noncoding RNAs (ncRNAs) perform functions through interaction with each other in various cellular processes.
Zhang, Xiaomeng, Wu, Deng, Chen, Liqun, Li, Xiang, Yang, Jinxurong, Fan, Dandan, Dong, Tingting, Liu, Mingyue, Tan, Puwen, Xu, Jintian, Yi, Ying, Wang, Yuting, Zou, Hua, Hu, Yongfei, Fan, Kaili, Kang, Juanjuan, Huang, Yan, Miao, Zhengqiang, Bi, Miaoman, Jin, Nana, Li, Kongning, Li, Xia, Xu, Jianzhen, Wang, Dong   +23 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

RNA Movies 2: sequential animation of RNA secondary structures [PDF]

, 2007
Kaiser A, Krüger J, Evers DJ. RNA Movies 2: sequential animation of RNA secondary structures. NUCLEIC ACIDS RESEARCH.
Krüger, Jan, Evers, Dirk J., Kaiser, Alexander   +2 more
core   +1 more source