Results 11 to 20 of about 1,370,770 (219)
Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes. [PDF]
PLoS ONE, 2017 Crimean Congo hemorrhagic fever, a zoonotic viral disease, has high mortality rate in humans. There is currently no vaccine for Crimean Congo hemorrhagic fever virus (CCHFV) and chemical interventions are limited.
Subbiah Jeeva +4 more
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Mechanism of RNA recognition by a Musashi RNA-binding protein
Current Research in Structural Biology, 2022 The Musashi RNA-binding proteins (RBPs) regulate translation of target mRNAs and maintenance of cell stemness and tumorigenesis. Musashi-1 (MSI1), long considered as an intestinal and neural stem cell marker, has been more recently found to be over ...
Jinan Wang +4 more
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PredPRBA: Prediction of Protein-RNA Binding Affinity Using Gradient Boosted Regression Trees
Frontiers in Genetics, 2019 Protein-RNA interactions play essential roles in many biological aspects. Quantifying the binding affinity of protein-RNA complexes is helpful to the understanding of protein-RNA recognition mechanisms and identification of strong binding partners.
Lei Deng, Lei Deng, Wenyi Yang, Hui Liu
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Helical defects in microRNA influence protein binding by TAR RNA binding protein.
PLoS ONE, 2015 BackgroundMicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most proteins from identifying their nucleotide sequence.
Roderico Acevedo +3 more
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RNA-binding protein signaling in adult neurogenesis
Frontiers in Cell and Developmental Biology, 2022 The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons.
Jackie Ngai-Man Chan +6 more
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Microbiology Spectrum, 2022 Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified.
Karunakaran Kalesh +5 more
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Technology in Cancer Research & Treatment, 2020 RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS +4 more
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Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins
Applied Sciences, 2020 RNAs play important roles in gene expression through translation and RNA splicing. Regulation of specific RNAs is useful to understand and manipulate specific transcripts.
Misaki Sugimoto +3 more
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Computational and Structural Biotechnology Journal, 2021 The interactions among non-coding RNA (ncRNA) and RNA binding protein (RBP) are increasingly recognized as one of basic mechanisms in gene regulation, and play a crucial role in cancer progressions.
Leiming Jiang +4 more
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Targeting RNA binding protein in prostate cancer
Molecular & Cellular Oncology, 2017 RNA binding protein (RBP) controls multiple aspects of RNA metabolism and plays crucial roles in many physiopathological contexts, including cancer. We recently identified an RBP HNRNPL as a novel prostate cancer dependency via regulation of RNA splicing,
Teng Fei
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