Results 11 to 20 of about 1,314,359 (264)
RNA-Binding Profiles of CKAP4 as an RNA-Binding Protein in Myocardial Tissues [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: Pathological tissue remodeling such as fibrosis is developed in various cardiac diseases. As one of cardiac activated-myofibroblast protein markers, CKAP4 may be involved in this process and the mechanisms have not been explored.Methods: We ...
Hong Zhu +7 more
doaj +3 more sources
PredPRBA: Prediction of Protein-RNA Binding Affinity Using Gradient Boosted Regression Trees
Frontiers in Genetics, 2019 Protein-RNA interactions play essential roles in many biological aspects. Quantifying the binding affinity of protein-RNA complexes is helpful to the understanding of protein-RNA recognition mechanisms and identification of strong binding partners.
Lei Deng, Lei Deng, Wenyi Yang, Hui Liu
doaj +3 more sources
Mechanism of RNA recognition by a Musashi RNA-binding protein [PDF]
Current Research in Structural Biology, 2022 The Musashi RNA-binding proteins (RBPs) regulate translation of target mRNAs and maintenance of cell stemness and tumorigenesis. Musashi-1 (MSI1), long considered as an intestinal and neural stem cell marker, has been more recently found to be over ...
Jinan Wang +4 more
doaj +3 more sources
An in vitro technique to identify the RNA binding-site sequences for RNA-binding proteins [PDF]
BioTechniques, 2017 RNA–protein interactions play a major role in gene regulation. Although many techniques to analyze RNA–protein interactions have been developed, noteworthy challenges such as determining the RNA sequences that bind RNA-binding proteins (RBPs) remain ...
SunKyung Choi +3 more
doaj +3 more sources
RNA‐PROTACs: Degraders of RNA‐Binding Proteins [PDF]
Angewandte Chemie International Edition, 2020 AbstractDefects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new class of drugs that mediate selective degradation of a target protein through a cell's ubiquitination machinery.
Alice Ghidini +4 more
openaire +6 more sources
The role of disorder in RNA binding affinity and specificity [PDF]
Open Biology, 2020 Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins typically attain the physiological specificity and affinity for their RNA targets by combining several RNA-binding modules.
Diana S. M. Ottoz, Luke E. Berchowitz
doaj +1 more source
The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
Frontiers in Oncology, 2021 The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs.
Zhigang Li +6 more
doaj +1 more source
WormBook, 2006 The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse genetics. They tend to display tissue-specific mutant phenotypes, which underscore their functional
Lee, Min'Ho, Schedl, Tim
openaire +3 more sources
Research progress of RNA binding motif protein family-mediated alternative splicing in cardiomyopathy [PDF]
Jichu yixue yu linchuang, 2022 RNA binding motif protein (RBM) is a type of RNA binding protein, which contains RNA recognition motif, RNA binding motif and ribo-nucleo-protein motif.
LIU Shu, DING Hong, ZHAO Ke-xin, BAI Feng, ZHANG Xiao-wei
doaj +1 more source
γ-AApeptides bind to RNA by mimicking RNA-binding proteins [PDF]
Organic & Biomolecular Chemistry, 2011 The interactions between proteins and RNAs are of vital importance for many cellular processes, including transcription and processing of RNA, translation, and viral infections. Here we report an γ-AApeptide that can mimic HIV-1 Tat protein and bind to TAR RNAs of HIV and BIV with nanomolar affinity, comparable to that of the RNA-binding fragment of ...
Youhong, Niu +4 more
openaire +2 more sources