Results 1 to 10 of about 1,122,786 (246)
RNA binding proteins in osteoarthritis
Frontiers in Cell and Developmental Biology, 2022 Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder.
Qian Yi +9 more
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RNA-Binding Proteins in Cardiomyopathies
Journal of Cardiovascular Development and DiseaseThe post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential ...
De-Li Shi
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RNA-binding proteins as versatile metabolic regulators [PDF]
npj Metabolic Health and DiseaseMetabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells.
Ellie Koletsou, Ina Huppertz
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The role of disorder in RNA binding affinity and specificity [PDF]
Open Biology, 2020 Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins typically attain the physiological specificity and affinity for their RNA targets by combining several RNA-binding modules.
Diana S. M. Ottoz, Luke E. Berchowitz
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WormBook, 2006 The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse genetics. They tend to display tissue-specific mutant phenotypes, which underscore their functional
Lee, Min'Ho, Schedl, Tim
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RNA binding proteins in MLL-rearranged leukemia
Experimental Hematology & Oncology, 2022 RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease.
Tiffany M. Tran, Dinesh S. Rao
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The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
eLife, 2021 TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains has ...
Juan Carlos Rengifo-Gonzalez +8 more
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RNA‐PROTACs: Degraders of RNA‐Binding Proteins [PDF]
Angewandte Chemie International Edition, 2020 AbstractDefects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new class of drugs that mediate selective degradation of a target protein through a cell's ubiquitination machinery.
Alice Ghidini +4 more
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RNA-binding proteins: TRAPping RNA bases [PDF]
Current Biology, 2000 In Bacillus subtilis, tryptophan biosynthesis is regulated by a mechanism called attenuation. The new crystal structure of the 'trp RNA binding attenuation protein', TRAP, in complex with RNA has provided new structural insights into how proteins can bind RNA to regulate transcription and translation.
Muto, Yutaka +2 more
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Frontiers in Molecular Neuroscience, 2021 Core spliceosome and related RNA-binding proteins aggregate in Alzheimer’s disease (AD) brain even in early asymptomatic stages (AsymAD) of disease.
Qi Guo +15 more
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