Results 51 to 60 of about 1,122,786 (246)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effects of RNA structure and salt concentration on the affinity and kinetics of interactions between pentatricopeptide repeat proteins and their RNA ligands.

PLoS ONE, 2018
Pentatricopeptide repeat (PPR) proteins are helical repeat proteins that bind specific RNA sequences via modular 1-repeat:1-nucleotide interactions. Binding specificity is dictated, in part, by hydrogen bonds between the amino acids at two positions in ...
James J McDermott, Bryce Civic, Alice Barkan   +2 more
doaj   +1 more source

Identification of Protein-RNA Interactions in Mouse Testis Tissue Using fRIP

Bio-Protocol, 2022
During development, cells must quickly switch from one cell state to the next to execute precise and timely differentiation. One method to ensure fast transitions in cell states is by controlling gene expression at the post-transcriptional level through ...
Alexis Bailey, Pedro Batista, Howard Chang, Margaret Fuller   +3 more
doaj   +1 more source

Alternative polyadenylation and RNA-binding proteins [PDF]

Journal of Molecular Endocrinology, 2016
Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA

Nature Communications, 2019
Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.
Ei-Wen Yang, Jae Hoon Bahn, Esther Yun-Hua Hsiao, Boon Xin Tan, Yiwei Sun, Ting Fu, Bo Zhou, Eric L. Van Nostrand, Gabriel A. Pratt, Peter Freese, Xintao Wei, Giovanni Quinones-Valdez, Alexander E. Urban, Brenton R. Graveley, Christopher B. Burge, Gene W. Yeo, Xinshu Xiao   +16 more
doaj   +1 more source

The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation

Cell Reports, 2015
TRIM-NHL proteins are conserved among metazoans and control cell fate decisions in various stem cell linages. The Drosophila TRIM-NHL protein Brain tumor (Brat) directs differentiation of neuronal stem cells by suppressing self-renewal factors.
Inga Loedige, Leonhard Jakob, Thomas Treiber, Debashish Ray, Mathias Stotz, Nora Treiber, Janosch Hennig, Kate B. Cook, Quaid Morris, Timothy R. Hughes, Julia C. Engelmann, Michael P. Krahn, Gunter Meister   +12 more
doaj   +1 more source

The characterization of RNA-binding proteins and RNA metabolism-related proteins in fungal extracellular vesicles

Frontiers in Cellular and Infection Microbiology, 2023
RNA-binding proteins (RBPs) are essential for regulating RNA metabolism, stability, and translation within cells. Recent studies have shown that RBPs are not restricted to intracellular functions and can be found in extracellular vesicles (EVs) in ...
Marianna Dallastella, Willian Klassen de Oliveira, Marcio L. Rodrigues, Marcio L. Rodrigues, Samuel Goldenberg, Lysangela R. Alves, Lysangela R. Alves   +6 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Predicting RNA-binding residues from evolutionary information and sequence conservation

BMC Genomics, 2010
Background RNA-binding proteins (RBPs) play crucial roles in post-transcriptional control of RNA. RBPs are designed to efficiently recognize specific RNA sequences after it is derived from the DNA sequence. To satisfy diverse functional requirements, RNA
Huang Chun-Chin, Chiu Li-Yuan, Huang Yu-Feng, Huang Chien-Kang   +3 more
doaj   +1 more source