Results 31 to 40 of about 28,766 (215)
Molecules, 2021 A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via polymethylene linkers to both nitrogen atoms of the heterocycle moiety (uracil, 6-methyluracil, thymine, quinazoline-2,4-dione ...
Olga V. Andreeva +13 more
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Life, 2023 Natural chiral amino acids typically adopt an L structural configuration. While a preference for specific molecular chiralities is observed throughout biology and cellular chemistry, the origins of this preference are unclear.
J. A. Cowan
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Practical Synthesis of Cap‐4 RNA
ChemBioChem, 2019 AbstractEukaryotic mRNAs possess 5′ caps that are determinants for their function. A structural characteristic of 5′ caps is methylation, with this feature already present in early eukaryotes such as Trypanosoma. While the common cap‐0 (m7GpppN) shows a rather simple methylation pattern, the Trypanosoma cap‐4 displays seven distinguished additional ...
Josef Leiter +3 more
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Staphylococcus aureus Small RNAs Possess Dephospho-CoA 5′-Caps, but No CoAlation Marks
Non-Coding RNA, 2022 Novel features of coenzyme A (CoA) and its precursor, 3′-dephospho-CoA (dpCoA), recently became evident. dpCoA was found to attach to 5′-ends of small ribonucleic acids (dpCoA-RNAs) in two bacterial species (Escherichia coli and Streptomyces venezuelae).
Christian Löcherer +3 more
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Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
Viruses, 2021 The ongoing COVID-19 pandemic exemplifies the general need to better understand viral infections. The positive single-strand RNA genome of its causative agent, the SARS coronavirus 2 (SARS-CoV-2), encodes all viral enzymes.
Roberto Benoni +5 more
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Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity
Viruses, 2022 In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of mutagens, driving viral populations to extinction.
Ikbel Hadj Hassine +2 more
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Development of Allosteric Ribozymes for ATP and l-Histidine Based on the R3C Ligase Ribozyme
LifeDuring the evolution of the RNA, short RNAs are thought to have joined together to form long RNAs, enhancing their function as ribozymes. Previously, the artificial R3C ligase ribozyme (73 nucleotides) was successfully reduced to 46 nucleotides; however,
Yuna Akatsu +2 more
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Circular RNAs and Their Emerging Roles in Immune Regulation
Frontiers in Immunology, 2018 Circular ribonucleic acid (RNA) molecules (circRNAs) are covalently closed loop RNA molecules with no 5′ end caps or 3′ poly (A) tails, which are generated by back-splicing.
Lan Yang +3 more
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Noncanonical metabolite
WIREs RNA, 2022 AbstractThe 5′ cap of eukaryotic mRNA is a hallmark for cellular functions from mRNA stability to translation. However, the discovery of novel 5′‐terminal RNA caps derived from cellular metabolites has challenged this long‐standing singularity in both eukaryotes and prokaryotes.
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Cap-independent translation of plant viral RNAs [PDF]
Virus Research, 2006 The RNAs of many plant viruses lack a 5' cap and must be translated by a cap-independent mechanism. Here, we discuss the remarkably diverse cap-independent translation elements that have been identified in members of the Potyviridae, Luteoviridae, and Tombusviridae families, and genus Tobamovirus.
Elizabeth L Pettit, Kneller +2 more
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