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DEGRADATION OF MESSENGER RNA IN MAMMALIAN CELLS

Acta Endocrinologica, 1972
ABSTRACT Analyses of the response of hydrocortisone-induced tyrosine transaminase in cultured H-35 cells to inhibitors of translation (cycloheximide, puromycin) suggest: (1) that bound ribosomes stabilize messenger RNA in vivo; (2) that messenger is degraded at a rate determined by the rate of translation.
F T, Kenney, K L, Lee, C D, Stiles
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Structural organization of the RNA-degrading exosome

Current Opinion in Structural Biology, 2008
The RNA exosome participates in the degradation and processing of a wide range of RNA molecules. Recent advances in understanding how the exosome is organized and functions largely stem from structural studies. Crystal structures of archaeal exosomes bound to RNA and of the corresponding nine-subunit human exosome core show that the archaeal and ...
Lorentzen, E., Basquin, J., Conti, Elena
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Wrong PH for RNA degradation

Nature Structural & Molecular Biology, 2007
The exosome, the major eukaryotic 3′ exoribonuclease acting in processing or degradation of a wide variety of RNA substrates, contains six subunits with predicted phosphorolytic activity and a single hydrolytic subunit. Recent data suggest that the phosphorolytic subunits of the yeast enzyme are catalytically inactive, and the hydrolytic subunit is ...
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Degrade the RNA

Nature Chemical Biology, 2023
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Eukaryotic messenger RNA degradation