Results 261 to 270 of about 962,124 (298)

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

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RNA Degradation in Eukaryotic Cells

Molecular Biology, 2020
RNA is a crucial component of every living organism and is necessary for gene expression and its regulation in the cell. Mechanisms of RNA synthesis (especially mRNA synthesis) were a subject of extensive study for a long time. More recently, RNA degradation pathways began to be considered as equally important part of eukaryotic cell metabolism.
K A, Tatosyan, I G, Ustyantsev, D A, Kramerov   +2 more
openaire   +2 more sources

Ultracentrifuge studies of RNA degradation

Archives of Biochemistry and Biophysics, 1962
Ultracentrifuge studies of RNA from Ehrlich ascites cells have shown that the original 28, 18, and 3–5 S components change progressively as a result of degradation. The 28 S component diminishes at a much more rapid rate than the 18 S, and their relative ratio changes as a function of the age of the RNA samples. Intermediary components of 24, 21, 15,
J, HUPPERT, J, PELMONT
openaire   +2 more sources

RNA Instant Quality Check: Alignment-Free RNA-Degradation Detection

Journal of Computational Biology, 2022
With the constant increase of large-scale genomic data projects, automated and high-throughput quality assessment becomes a crucial component of any analysis. Whereas small projects often have a more homogeneous design and a manageable structure allowing for a manual per-sample analysis of quality, large-scale studies tend to be much more heterogeneous
Kjong-van Lehmann, Andre Kahles, Magdalena Murr, Gunnar Rätsch   +3 more
openaire   +2 more sources

Messenger RNA degradation in Saccharomyces cerevisiae

Gene, 1988
The analysis of 17 functional mRNAs and two recombinant mRNAs in the yeast Saccharomyces cerevisiae suggests that the length of an mRNA influences its half-life in this organism. The mRNAs are clearly divisible into two populations when their lengths and half-lives are compared.
A J, Brown, I J, Purvis, T C, Santiago, A J, Bettany, L, Loughlin, J, Moore   +5 more
openaire   +2 more sources

Degradation of poliovirus RNA in vivo

Canadian Journal of Microbiology, 1973
From 15 to 20% of the RNA of virulent strains of poliovirus is degraded at 35 °C several hours after maximal synthesis is reached. From 20 to 30% of the RNA of attenuated viruses is degraded under the same conditions. Cultures placed at 40 °C in the presence of 3 mM guanidine during the linear stage of RNA synthesis lead to breakdown of 15 to 40% of ...
R, Adler, B D, Garfinkle, W, Mitchell, D R, Tershak   +3 more
openaire   +2 more sources

Diethyl pyrocarbonate does not degrade RNA

Biochemical and Biophysical Research Communications, 1975
Summary Diethyl pyrocarbonate, a compound extensively used as a nuclease inhibitor, reacts with low molecular weight RNA and forms products which are less precipitable with certain precipitating reagents than untreated RNA. This phenomenon, erroneously interpreted by Wiegers and Hilz (Biochem. Biophys. Res. Commun.
I, Fedorcsák, L, Ehrenberg, F, Solymosy
openaire   +2 more sources

Interferon, Double‐Stranded RNA and RNA Degradation

European Journal of Biochemistry, 1977
Extracts from interferon‐treated Ehrlich ascites tumor cells differ in various biochemical characteristics from extracts from control cells. Thus, as reported earlier, double‐stranded RNA (dsRNA) promotes the phosphorylation by ATP of at least two proteins in extracts from interferon‐treated cells, but not, or to only a lesser extent, in extracts from ...
Ratner, Lee, SEN, Ganes G.C., BROWN, Glenn G.E., Lebleu, Bernard, KAWAKITA, Masao, Cabrer, Bartolomé, SLATTERY, Elizabeth, LENGYEL, Peter   +7 more
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RNA-degrading activities in chicken liver

Biosystems, 1972
Abstract The occurrence, intra-cellular distribution and properties of ribonucleases in chicken liver were investigated. The pH-activity curve obtained with chicken liver cell-free preparation showed two pH optima, one at pH 5.0 and the other at pH 9.5. A considerable hydrolysis of RNA (yeast) over the pH range 7.0 to 9.0 was also observed.
openaire   +2 more sources