Results 1 to 10 of about 2,133,969 (419)
Population and allelic variation of A-to-I RNA editing in human transcriptomes [PDF]
Genome Biology, 2017 Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park +6 more
doaj +4 more sources
A model for codon position bias in RNA editing [PDF]
, 2005 RNA editing can be crucial for the expression of genetic information via inserting, deleting, or substituting a few nucleotides at specific positions in an RNA sequence. Within coding regions in an RNA sequence, editing usually occurs with a certain bias in choosing the positions of the editing sites.
Bundschuh, Ralf, Liu, Tsunglin
arxiv +5 more sources
Combining Insertion and Deletion in RNA-editing Preserves Regularity [PDF]
EPTCS 100, 2012, pp. 48-62, 2012 Inspired by RNA-editing as occurs in transcriptional processes in the living cell, we introduce an abstract notion of string adjustment, called guided rewriting. This formalism allows simultaneously inserting and deleting elements. We prove that guided rewriting preserves regularity: for every regular language its closure under guided rewriting is ...
Bošnački, D. +2 more
arxiv +6 more sources
RNA Editing and Its Roles in Plant Organelles
Frontiers in Genetics, 2021 RNA editing, a vital supplement to the central dogma, yields genetic information on RNA products that are different from their DNA templates. The conversion of C-to-U in mitochondria and plastids is the main kind of RNA editing in plants. Various factors
Wei Hao +12 more
doaj +2 more sources
Plant organellar RNA editing: what 30 years of research has revealed
Plant Journal, 2020 The central dogma in biology defines the flow of genetic information from DNA to RNA to protein. Accordingly, RNA molecules generally accurately follow the sequences of the genes from which they are transcribed.
Mareike Schallenberg-rüdinger +2 more
exaly +2 more sources
The Role of RNA Editing in Cancer Development and Metabolic Disorders [PDF]
Frontiers in Endocrinology, 2018 Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago.
Che-Pei Kung +6 more
doaj +3 more sources
RNA Polymerase RPOTp is Involved in C‐to‐U RNA Editing at Multiple Sites in Arabidopsis Chloroplasts [PDF]
Advanced ScienceRPOTp is the nuclear‐encoded plastid‐targeted RNA polymerase and plays a crucial role in chloroplast gene expression. Transcripts in plant organelles are altered by the conversion of cytidine (C) to uridine (U) at specific positions through RNA editing ...
Nadia Ahmed Ali +9 more
doaj +2 more sources
Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing
Nature Communications, 2023 CRISPR-Cas gene editing has revolutionized experimental molecular biology over the past decade and holds great promise for the treatment of human genetic diseases.
Jianli Tao, D. E. Bauer, R. Chiarle
semanticscholar +1 more source
N 1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Scientific Reports, 2022 In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N 1 ...
Tien-Hao Chen +4 more
doaj +1 more source
RNA: A publication of the RNA Society, 2023 The adaptiveness of nonsynonymous RNA editing (recoding) could be conferred by the flexibility of the temporal-spatially controllable proteomic diversity, or by its restorative effect which fixes unfavorable genomic mutations at the RNA level.
Y. Duan, W. Cai, Hu Li
semanticscholar +1 more source