Results 1 to 10 of about 447,271 (336)
RNA Editing: An I for editing [PDF]
Current Biology, 1995 In vitro editing in mammalian nuclear extracts reveals adenosine-to-inosine conversions in glutamate receptor messenger RNAs.
Brenda Bass
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RNA editing in kinetoplastid protozoa [PDF]
Microbiology and Molecular Biology Reviews, 1997 Mitochondrial transcripts in kinetoplastids undergo remarkable posttranscriptional editing by uridylate insertion and deletion. The often dramatic remodeling of pre-mRNA sequences is directed by small guide RNAs (gRNAs) to produce mature mRNAs. In vitro analyses of editing have been used to determine the mechanism of editing and show that editing ...
Ken Stuart +3 more
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RNA Polymerase RPOTp is Involved in C‐to‐U RNA Editing at Multiple Sites in Arabidopsis Chloroplasts [PDF]
Advanced ScienceRPOTp is the nuclear‐encoded plastid‐targeted RNA polymerase and plays a crucial role in chloroplast gene expression. Transcripts in plant organelles are altered by the conversion of cytidine (C) to uridine (U) at specific positions through RNA editing ...
Nadia Ahmed Ali +9 more
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FEMS Microbiology Reviews, 1999 The term RNA editing describes those molecular processes in which the information content is altered in an RNA molecule. To date such changes have been observed in tRNA. rRNA and mRNA molecules of eukaryotes, but not prokaryotes. The demonstration of RNA editing in prokaryotes may only be a matter of time, considering the range of species in which the ...
K A, Holland +3 more
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N 1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Scientific Reports, 2022 In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N 1 ...
Tien-Hao Chen +4 more
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RNA editing regulates lncRNA splicing in human early embryo development.
PLoS Computational Biology, 2021 RNA editing is a co- or post-transcriptional modification through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after transcription.
Jiajun Qiu +3 more
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Forestry Research, 2021 RNA-editing is a post-transcriptional modification that can diversify genome-encoded information by modifying individual RNA bases. In contrast to the well-studied RNA-editing in organelles, little is known about nuclear RNA-editing in higher plants.
Yiran Wang +3 more
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Aptamer-Based In Vivo Therapeutic Targeting of Glioblastoma
Molecules, 2020 Glioblastoma (GBM) is the most aggressive, infiltrative, and lethal brain tumor in humans. Despite the extensive advancement in the knowledge about tumor progression and treatment over the last few years, the prognosis of GBM is still very poor due to ...
Valeriana Cesarini +6 more
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RNA Biology, 2010 In plants, post-transcriptional modification of transcripts includes C-to-U, U-to-C and A-to-I editing. RNA editing in plants is essential, with many mutants impaired in editing of specific sites exhibiting strong deleterious phenotypes, even lethality.
Chateigner-Boutin, Anne Laure +1 more
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RNA editing: Expanding the potential of RNA therapeutics [PDF]
Molecular Therapy, 2023 RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic. In addition, RNA-targeting drugs have been developed for diseases with significant unmet medical needs through selective mRNA knockdown or modulation of pre-mRNA splicing.
Brian J. Booth +7 more
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