Population and allelic variation of A-to-I RNA editing in human transcriptomes [PDF]
Genome Biology, 2017 Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park +6 more
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The Role of RNA Editing in Cancer Development and Metabolic Disorders [PDF]
Frontiers in Endocrinology, 2018 Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago.
Che-Pei Kung +6 more
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ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
Nature Communications, 2021 Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I ...
Sonia Jimeno +16 more
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RNA Editing and Its Roles in Plant Organelles
Frontiers in Genetics, 2021 RNA editing, a vital supplement to the central dogma, yields genetic information on RNA products that are different from their DNA templates. The conversion of C-to-U in mitochondria and plastids is the main kind of RNA editing in plants. Various factors
Wei Hao +12 more
doaj +2 more sources
C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia [PDF]
Scientific ReportsCytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases.
Alejandra Gonzalez Martinez +14 more
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RNA editing underlies genetic risk of common inflammatory diseases
Nature, 2022 Qin Li, Francois Aguet
exaly +2 more sources
RNA Polymerase RPOTp is Involved in C‐to‐U RNA Editing at Multiple Sites in Arabidopsis Chloroplasts [PDF]
Advanced ScienceRPOTp is the nuclear‐encoded plastid‐targeted RNA polymerase and plays a crucial role in chloroplast gene expression. Transcripts in plant organelles are altered by the conversion of cytidine (C) to uridine (U) at specific positions through RNA editing ...
Nadia Ahmed Ali +9 more
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Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing
Nature Communications, 2023 CRISPR-Cas gene editing has revolutionized experimental molecular biology over the past decade and holds great promise for the treatment of human genetic diseases.
Jianli Tao, D. E. Bauer, R. Chiarle
semanticscholar +1 more source
N 1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Scientific Reports, 2022 In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N 1 ...
Tien-Hao Chen +4 more
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RNA: A publication of the RNA Society, 2023 The adaptiveness of nonsynonymous RNA editing (recoding) could be conferred by the flexibility of the temporal-spatially controllable proteomic diversity, or by its restorative effect which fixes unfavorable genomic mutations at the RNA level.
Y. Duan, W. Cai, Hu Li
semanticscholar +1 more source