Results 11 to 20 of about 447,271 (336)
RNA editing in kinetoplastids [PDF]
RNA Biology, 2010 RNA editing in kinetoplastid protozoa is a post-transcriptional process of uridine insertion or deletion in mitochondrial mRNAs. The process involves two RNA species, the pre-edited mRNA and in most cases a trans-acting guide RNA (gRNA). Sequences within gRNAs define the position and extend of mRNA editing.
Stephen L. Hajduk, Torsten Ochsenreiter
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Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Chanjing Feng +8 more
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Comprehensive high-resolution analysis of the role of an Arabidopsis gene family in RNA editing. [PDF]
PLoS Genetics, 2013 In flowering plants, mitochondrial and chloroplast mRNAs are edited by C-to-U base modification. In plant organelles, RNA editing appears to be generally a correcting mechanism that restores the proper function of the encoded product.
Stéphane Bentolila +3 more
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RNA Editing and Retrotransposons in Neurology [PDF]
Frontiers in Molecular Neuroscience, 2018 Compared to sites in protein-coding sequences many more targets undergoing adenosine to inosine (A-to-I) RNA editing were discovered in non-coding regions of human cerebral transcripts, particularly in genetic transposable elements called retrotransposons. We review here the interaction mechanisms of RNA editing and retrotransposons and their impact on
Heinz Krestel +2 more
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The landscape of coding RNA editing events in pediatric cancer
BMC Cancer, 2021 Background RNA editing leads to post-transcriptional variation in protein sequences and has important biological implications. We sought to elucidate the landscape of RNA editing events across pediatric cancers.
Ji Wen +12 more
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E-I balance and human diseases - from molecules to networking
Frontiers in Molecular Neuroscience, 2008 Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development.
Sabrina A Eichler, Jochen C Meier
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Genome Biology, 2019 Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. Results Here, we characterize the inosinome signature in normal brain and de novo
Domenico Alessandro Silvestris +9 more
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Frontiers in Oncology, 2020 RNA editing is a widespread post-transcriptional mechanism to introduce single nucleotide changes to RNA in human cancers. Here, we characterized the global RNA editing profiles of 373 hepatocellular carcinoma (HCC) and 50 adjacent normal liver samples ...
Juan Chen +5 more
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Survey of the binding preferences of RNA-binding proteins to RNA editing events
Genome Biology, 2022 Background Adenosine-to-inosine (A-to-I) editing is an important RNA posttranscriptional process related to a multitude of cellular and molecular activities.
Xiaolin Hu, Qin Zou, Li Yao, Xuerui Yang
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Frontiers in Molecular Neuroscience, 2009 Information processing in the brain requires a delicate balance between excitation and inhibition. Glycine receptors (GlyR) are involved in inhibitory mechanisms mainly at a synaptic level, but potential novel roles for these receptors recently emerged ...
Pascal Legendre +6 more
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