Results 11 to 20 of about 2,133,969 (419)
RNA Editing: An I for editing [PDF]
Current Biology, 1995 In vitro editing in mammalian nuclear extracts reveals adenosine-to-inosine conversions in glutamate receptor messenger RNAs.
Brenda Bass
openalex +5 more sources
RNA editing: Expanding the potential of RNA therapeutics [PDF]
Molecular Therapy, 2023 RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic. In addition, RNA-targeting drugs have been developed for diseases with significant unmet medical needs through selective mRNA knockdown or modulation of pre-mRNA splicing.
B. Booth +7 more
semanticscholar +4 more sources
RNA editing in kinetoplastid protozoa [PDF]
Microbiology and Molecular Biology Reviews, 1997 Mitochondrial transcripts in kinetoplastids undergo remarkable posttranscriptional editing by uridylate insertion and deletion. The often dramatic remodeling of pre-mRNA sequences is directed by small guide RNAs (gRNAs) to produce mature mRNAs. In vitro analyses of editing have been used to determine the mechanism of editing and show that editing ...
Ken Stuart +3 more
openalex +4 more sources
RNA editing with CRISPR-Cas13 [PDF]
Science, 2017 Precise transcriptome engineering Efficient and precise RNA editing to correct disease-relevant transcripts holds great promise for treating genetic disease. Cox et al. took advantage of the ability of Cas13b, an effector from a type VI CRISPR-Cas system, to target specific RNAs directly (see the ...
David B. T. Cox +6 more
semanticscholar +6 more sources
RNA Editing in Pathogenesis of Cancer [PDF]
Cancer Research, 2017 Several adenosine or cytidine deaminase enzymes deaminate transcript sequences in a cell type or environment-dependent manner by a programmed process called RNA editing.
Baysal, Bora E. +3 more
core +5 more sources
FEMS Microbiology Reviews, 1999 The term RNA editing describes those molecular processes in which the information content is altered in an RNA molecule. To date such changes have been observed in tRNA. rRNA and mRNA molecules of eukaryotes, but not prokaryotes. The demonstration of RNA editing in prokaryotes may only be a matter of time, considering the range of species in which the ...
A, Brennicke, A, Marchfelder, S, Binder
+8 more sources
RNA editing regulates lncRNA splicing in human early embryo development.
PLoS Computational Biology, 2021 RNA editing is a co- or post-transcriptional modification through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after transcription.
Jiajun Qiu +3 more
doaj +1 more source
Forestry Research, 2021 RNA-editing is a post-transcriptional modification that can diversify genome-encoded information by modifying individual RNA bases. In contrast to the well-studied RNA-editing in organelles, little is known about nuclear RNA-editing in higher plants.
Yiran Wang +3 more
doaj +1 more source
Aptamer-Based In Vivo Therapeutic Targeting of Glioblastoma
Molecules, 2020 Glioblastoma (GBM) is the most aggressive, infiltrative, and lethal brain tumor in humans. Despite the extensive advancement in the knowledge about tumor progression and treatment over the last few years, the prognosis of GBM is still very poor due to ...
Valeriana Cesarini +6 more
doaj +1 more source
Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
bioRxiv, 2020 The COVID-19 outbreak has become a global health risk and understanding the response of the host to the SARS-CoV-2 virus will help to contrast the disease.
S. Di Giorgio +4 more
semanticscholar +2 more sources