Results 11 to 20 of about 685,668 (343)
Population and allelic variation of A-to-I RNA editing in human transcriptomes [PDF]
Genome Biology, 2017 Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park +6 more
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The Role of RNA Editing in Cancer Development and Metabolic Disorders [PDF]
Frontiers in Endocrinology, 2018 Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago.
Che-Pei Kung +6 more
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C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia [PDF]
Scientific ReportsCytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases.
Alejandra Gonzalez Martinez +14 more
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FEMS Microbiology Reviews, 1999 The term RNA editing describes those molecular processes in which the information content is altered in an RNA molecule. To date such changes have been observed in tRNA. rRNA and mRNA molecules of eukaryotes, but not prokaryotes. The demonstration of RNA editing in prokaryotes may only be a matter of time, considering the range of species in which the ...
A, Brennicke, A, Marchfelder, S, Binder
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Characterization of RNA editing gene APOBEC3C as a candidate tumor suppressor in prostate cancer. [PDF]
Sci RepWang LY +9 more
europepmc +3 more sources
N 1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Scientific Reports, 2022 In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N 1 ...
Tien-Hao Chen +4 more
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RNA editing regulates lncRNA splicing in human early embryo development.
PLoS Computational Biology, 2021 RNA editing is a co- or post-transcriptional modification through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after transcription.
Jiajun Qiu +3 more
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RNA Biology, 2010 In plants, post-transcriptional modification of transcripts includes C-to-U, U-to-C and A-to-I editing. RNA editing in plants is essential, with many mutants impaired in editing of specific sites exhibiting strong deleterious phenotypes, even lethality.
Chateigner-Boutin, Anne Laure +1 more
openaire +2 more sources
Forestry Research, 2021 RNA-editing is a post-transcriptional modification that can diversify genome-encoded information by modifying individual RNA bases. In contrast to the well-studied RNA-editing in organelles, little is known about nuclear RNA-editing in higher plants.
Yiran Wang +3 more
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Aptamer-Based In Vivo Therapeutic Targeting of Glioblastoma
Molecules, 2020 Glioblastoma (GBM) is the most aggressive, infiltrative, and lethal brain tumor in humans. Despite the extensive advancement in the knowledge about tumor progression and treatment over the last few years, the prognosis of GBM is still very poor due to ...
Valeriana Cesarini +6 more
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