Results 241 to 250 of about 2,153,086 (396)

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

Advanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang, Biying Dong, Jie Chen, Zhenqiang Zhang, Weitong Zeng, Longxiong Liao, Xia Xiong, Xuejun Qin, Xianming Fan   +8 more
wiley   +1 more source

RNA editing in disease: mechanisms and therapeutic potential. [PDF]

RNA
Tamizkar KH, Jantsch MF.
europepmc   +1 more source

Mutagenesis of Apobec-1 Complementation Factor Reveals Distinct Domains That Modulate RNA Binding, Protein-Protein Interaction with Apobec-1, and Complementation of C to U RNA-editing Activity [PDF]

, 2001
Valérie Blanc, Jeffrey O. Henderson, Susan Kennedy, Nicholas O. Davidson   +3 more
openalex   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source

Massive RNA Editing in Ascetosporean Mitochondria. [PDF]

Microbes Environ
Yabuki A, Fujii C, Yazaki E, Tame A, Mizuno K, Obayashi Y, Takao Y.   +6 more
europepmc   +1 more source

ADARs have effects beyond RNA editing [PDF]

, 2009
Heale, Bret S E, Keegan, Liam P, O'Connell, Mary A   +2 more
core   +1 more source

The Zab Domain of the Human RNA Editing Enzyme ADAR1 Recognizes Z-DNA When Surrounded by B-DNA

, 2000
Yang‐Gyun Kim, Ky Lowenhaupt, Stefan Maas, Alan Herbert, Thomas Schwartz, Alexander Rich   +5 more
openalex   +1 more source

RNA Editing of the Human Serotonin 5-HT2C Receptor Alterations in Suicide and Implications for Serotonergic Pharmacotherapy [PDF]

, 2001
Colleen M. Niswender
openalex   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells. [PDF]

Mol Metab
Peleg S, Zamashanski L, Belin J, Novoselsky R, Cohen-Fultheim R, Knebel UE, Glaser B, Itzkovitz S, Kaestner KH, Powers AC, Levanon EY, Klochendler A, Dor Y.   +12 more
europepmc   +1 more source