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RNA Editing in Interferonopathies
, 2020 The type I interferonopathies comprise a heterogenous group of monogenic diseases associated with a constitutive activation of type I interferon signaling.The elucidation of the genetic causes of this group of diseases revealed an alteration of nucleic acid processing and signaling.ADAR1 is among the genes found mutated in patients with this type of ...
Frassinelli L. +3 more
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, 2015 This chapter discusses how open reading frames (ORFs) of some RNAs can be altered after transcription by RNA editing. The chapter highlights the important role RNA editing plays in keeping selfish DNA elements in the genome in check. It also mentions the significant role RNA editing plays in enabling tRNAs to translate mRNAs efficiently, which is a ...
David Elliott, Michael Ladomery
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Annual Review of Neuroscience, 1996
RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum ...
L, Simpson, R B, Emeson
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RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum ...
L, Simpson, R B, Emeson
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On the evolution of RNA editing
Trends in Genetics, 1993The term 'RNA editing' encompasses a variety of processes that change the primary nucleotide sequence of an RNA transcript from that of its encoding DNA. As in the case of certain other molecular genetic phenomena, for example RNA splicing, the discovery of RNA editing presented molecular biologists with an evolutionary puzzle, since the existence of ...
P S, Covello, M W, Gray
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WIREs RNA, 2011
AbstractRNA editing is a term used for a number of mechanistically different processes that alter the nucleotide sequence of RNA molecules to differ from the gene sequence. RNA editing occurs in a wide variety of organisms and is particularly frequent in organelle transcripts of eukaryotes.
Chateigner Boutin, Anne Laure +1 more
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AbstractRNA editing is a term used for a number of mechanistically different processes that alter the nucleotide sequence of RNA molecules to differ from the gene sequence. RNA editing occurs in a wide variety of organisms and is particularly frequent in organelle transcripts of eukaryotes.
Chateigner Boutin, Anne Laure +1 more
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Molecular Biology, 2007
RNA editing is a collective term referring to a plethora of reactions that ultimately lead to changes in RNA nucleotide sequence apart from splicing, 5' capping or 3' end processing. Spread throughout the Eukarya, RNA editing creates genetic information de novo, alters decoding capacity, or influences structure and stability of RNA by inserting ...
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RNA editing is a collective term referring to a plethora of reactions that ultimately lead to changes in RNA nucleotide sequence apart from splicing, 5' capping or 3' end processing. Spread throughout the Eukarya, RNA editing creates genetic information de novo, alters decoding capacity, or influences structure and stability of RNA by inserting ...
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Partially edited RNAs are intermediates of RNA editing in plant mitochondria
The Plant Journal, 2006SummaryRNA editing in flowering plant mitochondria addresses several hundred specific C nucleotides in individual sequence contexts in mRNAs and tRNAs. Many of the in vivo steady state RNAs are edited at some sites but not at others. It is still unclear whether such incompletely edited RNAs can either be completed or are aborted.
Daniil, Verbitskiy +4 more
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RNA editing: getting U into RNA
Trends in Biochemical Sciences, 1997RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable
M L, Kable, S, Heidmann, K D, Stuart
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Current Opinion in Cell Biology, 1991
Since its discovery, RNA editing in kinetoplastid mitochondria has proven a fascinating topic of study, and the last one and a half years have witnessed enormous advances in our understanding of this unprecedented form of RNA processing. The information flow in this RNA editing, once considered a candidate for defying the central dogma, is now known to
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Since its discovery, RNA editing in kinetoplastid mitochondria has proven a fascinating topic of study, and the last one and a half years have witnessed enormous advances in our understanding of this unprecedented form of RNA processing. The information flow in this RNA editing, once considered a candidate for defying the central dogma, is now known to
openaire +2 more sources
European Journal of Biochemistry, 1994
The nucleotide sequence of mitochondrial pre‐mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by massive editing which can produce more
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The nucleotide sequence of mitochondrial pre‐mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by massive editing which can produce more
openaire +2 more sources