Results 21 to 30 of about 2,133,969 (419)
RNA editing in kinetoplastids [PDF]
RNA Biology, 2010 RNA editing in kinetoplastid protozoa is a post-transcriptional process of uridine insertion or deletion in mitochondrial mRNAs. The process involves two RNA species, the pre-edited mRNA and in most cases a trans-acting guide RNA (gRNA). Sequences within gRNAs define the position and extend of mRNA editing.
Stephen L. Hajduk, Torsten Ochsenreiter
openaire +3 more sources
The landscape of coding RNA editing events in pediatric cancer
BMC Cancer, 2021 Background RNA editing leads to post-transcriptional variation in protein sequences and has important biological implications. We sought to elucidate the landscape of RNA editing events across pediatric cancers.
Ji Wen +12 more
doaj +1 more source
Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Chanjing Feng +8 more
doaj +1 more source
Nature Biotechnology, 2021 Recruiting endogenous adenosine deaminases using exogenous guide RNAs to edit cellular RNAs is a promising therapeutic strategy, but editing efficiency and durability remain low using current guide RNA designs.
Dhruva Katrekar +6 more
semanticscholar +1 more source
RNA Biology, 2010 In plants, post-transcriptional modification of transcripts includes C-to-U, U-to-C and A-to-I editing. RNA editing in plants is essential, with many mutants impaired in editing of specific sites exhibiting strong deleterious phenotypes, even lethality.
Chateigner-Boutin, Anne Laure +1 more
openaire +3 more sources
Comprehensive high-resolution analysis of the role of an Arabidopsis gene family in RNA editing. [PDF]
PLoS Genetics, 2013 In flowering plants, mitochondrial and chloroplast mRNAs are edited by C-to-U base modification. In plant organelles, RNA editing appears to be generally a correcting mechanism that restores the proper function of the encoded product.
Stéphane Bentolila +3 more
doaj +1 more source
Nature Communications, 2021 ADAR1 is involved in adenosine-to-inosine RNA editing. The cytoplasmic ADAR1p150 edits 3’UTR double-stranded RNAs and thereby suppresses induction of interferons.
Yusuke Shiromoto +4 more
semanticscholar +1 more source
Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]
, 2002 RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H. +2 more
core +1 more source
E-I balance and human diseases - from molecules to networking
Frontiers in Molecular Neuroscience, 2008 Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development.
Sabrina A Eichler, Jochen C Meier
doaj +1 more source
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source