Results 21 to 30 of about 447,271 (336)
Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues. [PDF]
PLoS ONE, 2012 RNA editing is a process that modifies RNA nucleotides and changes the efficiency and fidelity of the central dogma. Enzymes that catalyze RNA editing are required for life, and defects in RNA editing are associated with many diseases. Recent advances in
Tongjun Gu +5 more
doaj +1 more source
On the origin and evolution of RNA editing in metazoans [PDF]
Cell Reports, 2020 AbstractExtensive adenosine-to-inosine (A-to-I) editing of nuclear-transcribed RNAs is the hallmark of metazoan transcriptional regulation, and is fundamental to numerous biochemical processes. Here we explore the origin and evolution of this regulatory innovation, by quantifying its prevalence in 22 species that represent all major transitions in ...
Qunfei Guo +20 more
openaire +7 more sources
Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections
Frontiers in Immunology, 2023 BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Zhi-Yuan Wei +30 more
doaj +1 more source
Is abundant A-to-I RNA editing primate-specific? [PDF]
Trends in Genetics, Vol. 21, 77-81 (2005), 2004 A-To-I RNA editing is common to all eukaryotes, associated with various neurological functions. Recently, A-to-I editing was found to occur abundantly in the human transcriptome. Here we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher as that of mouse, rat, chicken or fly.
arxiv +1 more source
RNA editing of human microRNAs [PDF]
Genome Biology, 2006 Abstract Background MicroRNAs (miRNAs) are short RNAs of around 22 nucleotides that regulate gene expression. The primary transcripts of miRNAs contain double-stranded RNA and are therefore potential substrates for adenosine to inosine (A-to-I) RNA editing ...
Blow, Matthew J +7 more
openaire +4 more sources
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
Nature Communications, 2021 Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I ...
Sonia Jimeno +16 more
doaj +1 more source
A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects
Frontiers in Oncology, 2021 As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported.
Heming Wang +9 more
doaj +1 more source
Genomic Positional Dissection of RNA Editomes in Tumor and Normal Samples
Frontiers in Genetics, 2019 RNA editing is phenomenon that occurs in both protein coding and non-coding RNAs. Increasing evidence have shown that adenosine-to-inosine RNA editing can potentially rendering substantial functional effects throughout the genome.
Michael Chigaev +8 more
doaj +1 more source
RNA Editing in Chloroplasts of Spirodela polyrhiza, an Aquatic Monocotelydonous Species. [PDF]
PLoS ONE, 2015 RNA editing is the post-transcriptional conversion from C to U before translation, providing a unique feature in the regulation of gene expression.
Wenqin Wang +4 more
doaj +1 more source
The Role of RNA Editing in Cancer Development and Metabolic Disorders
Frontiers in Endocrinology, 2018 Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago.
Che-Pei Kung +6 more
doaj +1 more source