Results 31 to 40 of about 2,153,086 (396)

Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. Results Here, we characterize the inosinome signature in normal brain and de novo
Domenico Alessandro Silvestris, Ernesto Picardi, Valeriana Cesarini, Bruno Fosso, Nicolò Mangraviti, Luca Massimi, Maurizio Martini, Graziano Pesole, Franco Locatelli, Angela Gallo   +9 more
doaj   +1 more source

The landscape of coding RNA editing events in pediatric cancer

BMC Cancer, 2021
Background RNA editing leads to post-transcriptional variation in protein sequences and has important biological implications. We sought to elucidate the landscape of RNA editing events across pediatric cancers.
Ji Wen, Michael Rusch, Samuel W. Brady, Ying Shao, Michael N. Edmonson, Timothy I. Shaw, Brent B. Powers, Liqing Tian, John Easton, Charles G. Mullighan, Tanja Gruber, David Ellison, Jinghui Zhang   +12 more
doaj   +1 more source

A model for codon position bias in RNA editing [PDF]

, 2005
RNA editing can be crucial for the expression of genetic information via inserting, deleting, or substituting a few nucleotides at specific positions in an RNA sequence. Within coding regions in an RNA sequence, editing usually occurs with a certain bias
Bundschuh, Ralf, Liu, Tsunglin
core   +2 more sources

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Science, 2015
RNA editing helps identify cellular RNAs Adenosine bases in messenger RNA (mRNAs) can be enzymatically modified and changed into inosine bases. This RNA “editing” is mediated by adenosine deaminase acting on RNA (ADAR) enzymes. Liddicoat et al. show that
Brian J. Liddicoat, Robert Piskol, A. Chalk, Gokul Ramaswami, M. Higuchi, Jochen C. Hartner, J. B. Li, P. Seeburg, Carl R Walkley   +8 more
semanticscholar   +1 more source

The role of RNA editing enzyme ADAR1 in human disease

Wiley Interdisciplinary Reviews - RNA, 2021
Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of missense mutations in coding sequences.
B. Song, Yusuke Shiromoto, Moeko Minakuchi, K. Nishikura   +3 more
semanticscholar   +1 more source

Glycine receptors caught between genome and proteome - functional implications of RNA editing and splicing

Frontiers in Molecular Neuroscience, 2009
Information processing in the brain requires a delicate balance between excitation and inhibition. Glycine receptors (GlyR) are involved in inhibitory mechanisms mainly at a synaptic level, but potential novel roles for these receptors recently emerged ...
Pascal Legendre, Pascal Legendre, Pascal Legendre, Benjamin Förstera, Benjamin Förstera, Rene Jüttner, Jochen C Meier   +6 more
doaj   +1 more source

Genomic Identification of RNA Editing Through Integrating Omics Datasets and the Clinical Relevance in Hepatocellular Carcinoma

Frontiers in Oncology, 2020
RNA editing is a widespread post-transcriptional mechanism to introduce single nucleotide changes to RNA in human cancers. Here, we characterized the global RNA editing profiles of 373 hepatocellular carcinoma (HCC) and 50 adjacent normal liver samples ...
Juan Chen, Lu Wang, Fangbin Wang, Jian Liu, Jian Liu, Zhenyu Bai   +5 more
doaj   +1 more source

Genome-wide characterization of RNA editing highlights roles of high editing events of glutamatergic synapse during mouse retinal development

Computational and Structural Biotechnology Journal, 2022
Adenosine-to-inosine (A-to-I) RNA editing leads to functional change of neurotransmitter receptor which is essential for neurotransmission and normal neuronal development. As a highly accessible part of central nervous system, retina has been extensively
Chenghao Li, Xinrui Shi, Jiaying Yang, Ke Li, Lijun Dai, Yan Zhang, Meng Zhou, Jianzhong Su   +7 more
doaj   +1 more source

Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]

, 2002
RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H., Jaikaran, Dominic C. J., MacMillan, Andrew M.   +2 more
core   +1 more source

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Achim Schnaufer, Alatortsev, Ammerman, Aphasizheva, Aphasizheva, Bailey, Borst, Carnes, Carnes, Carnes, Cruz-Reyes, Cruz-Reyes, Deschamps, Ernst, Ernst, Etheridge, Fisk, Guo, Guo, Guo, Hashimi, Igo, Igo, Inoue, Jason Carnes, Jensen, Kao, Kenneth Stuart, Koslowsky, Koslowsky, Lukes, Mattiacio, Mattiacio, Melissa Lerch, Militello, Nathalie Acestor, Niemann, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Piller, Rigaut, Ryan, Sabatini, Schnaufer, Schnaufer, Seiwert, Simpson, Stuart, Trotter, Weng, Wirtz, Worthey, Xuemin Guo, Zhang   +58 more
core   +1 more source