Results 111 to 120 of about 2,276,335 (391)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

RNA modified with acyclic threoninol nucleic acids for RNA interference [PDF]

, 2015
Upon the discovery of the RNA interference pathway, the development of nucleic acids derivatives for therapeutic purposes has soon caught the attention of biomedical researchers.
Alagia, Adele, Eritja Casadellà, Ramón, Terrazas, Montserrat   +2 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Salicylic acid collaborates with gene silencing to tomato defense against tomato yellow leaf curl virus (TYLCV) [PDF]

, 2018
Antiviral research in plants has been focused on RNA silencing (i.e. RNA interference), and several studies suggest that salicylic acid (SA)-mediated resistance is a key part of plant antiviral defense.
Crabbe, M. James C., Li, Yunzhou, Liang, Yan, Muhammad, Tayab, Wang, Yong, Zhang, Dalong   +5 more
core  

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design [PDF]

, 2011
A
Albrechtsen, Merete, An, Chunju, Aymeric, Jean-Luc, Barthel, Andrea, Bebas, Piotr, Bitra, Kavita, Bravo, Alejandra, Chevalier, François, Collinge, Derek P, Crava, Cristina M, de Maagd, Ruud A, Duvic, Bernard, Eleftherianos, Ioannis, Erlandson, Martin, Faye, Ingrid, Felföldi, Gabriella, ffrench-Constant, Richard H, Fujiwara, Haruhiko, Futahashi, Ryo, Gandhe, Archana S, Garbutt, Jennie S, Gatehouse, Heather S, Gatehouse, Laurence N, Giebultowicz, Jadwiga, Gordon, Karl, Grimmelikhuijzen, Cornelis, Groot, Astrid T, Gómez, Isabel, Hauser, Frank, Heckel, David G, Hegedus, Dwayne D, Herrero, Salvador, Hrycaj, Steven, Huang, Lihua, Hull, J Joe, Huvenne, Hanneke, Iatrou, Kostas, Iga, Masatoshi, Kanost, Michael R, Kotwica, Joanna, Li, Changyou, Li, Jianghong, Liu, Jisheng, Lundmark, Magnus, Matsumoto, Shogo, Meyering-Vos, Martina, Millichap, Peter J, Monteiro, Antónia, Mrinal, Nirotpal, Nagaraju, Javaregowda, Niimi, Teruyuki, Nowara, Daniela, Ohnishi, Atsushi, Oostra, Vicencio, Ozaki, Katsuhisa, Papakonstantinou, Maria, Papanicolaou, Alexie, Popadic, Aleksandar, Rajam, Manchikatla V, Saenko, Suzanne, Simpson, Robert M, Smagghe, Guy, Soberón, Mario, Sriramana, Kanginakudru, Strand, Michael R, Swevers, Luc, Terenius, Olle, Tomita, Shuichiro, Toprak, Umut, Wang, Ping, Wei Wee, Choon, Whyard, Steven, Zhang, Wenqing   +72 more
core   +3 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axisResearch in context

EBioMedicine, 2019
Background: Inflammatory mediator prostaglandin E2–prostaglandin E2 receptor EP3 (PTGER3) signaling is critical for tumor-associated angiogenesis, tumor growth, and chemoresistance. However, the mechanism underlying these effects in ovarian cancer is not
Cristian Rodriguez-Aguayo, Emine Bayraktar, Cristina Ivan, Burcu Aslan, Junhua Mai, Guangan He, Lingegowda S. Mangala, Dahai Jiang, Archana S. Nagaraja, Bulent Ozpolat, Arturo Chavez-Reyes, Mauro Ferrari, Rahul Mitra, Zahid H. Siddik, Haifa Shen, Xianbin Yang, Anil K. Sood, Gabriel Lopez-Berestein   +17 more
doaj  

Suppression of Argonaute 2 Transcript Levels in Du182A Cells [PDF]

, 2018
RNA interference (RNAi) uses double-stranded RNA (dsRNA) molecules to degrade and suppress the transcript level of a complementary mRNA target1.
Featherston, Kyah, Schneck, Karen, Silver, Kristopher   +2 more
core  

RNA interference is essential for cellular quiescence

Science, 2016
RNAi soothes the path to quiescence Cells, such as those in stem cell niches and immunity memory cells, can exist in a nondividing, quiescent state, from which they can be aroused with the appropriate signal.
B. Roche, B. Arcangioli, R. Martienssen
semanticscholar   +1 more source

RNA interference revolution

Electronic Journal of Biotechnology, 2003
RNA interference (RNAi) is a potent method using only a few double stranded RNA (dsRNA) molecule per cell to silence the expression which has made it one of the hottest topics in molecular biology in last two years. Not long ago scientists conducted gene knock out using antisense, dominant negative or knockout techniques which were ineffective, but the
openaire   +3 more sources