Results 51 to 60 of about 74,683 (214)

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Nanotechnology Enhanced RNAi Therapies in Cancer: A Systematic Review

Journal of Cancer Biomoleculars and Therapeutics
Cancer remains a major cause of illness and death worldwide, with conventional treatments often hindered by systemic toxicity, lack of specificity, and the development of resistance.
Muhammad Abid Mustafa, Namra Rasheed
doaj   +1 more source

Nano-based delivery of RNAi in cancer therapy

Molecular Cancer, 2017
Background RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention.
Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang, Guan Jiang   +5 more
doaj   +1 more source

Viral suppressors of RNA silencing hinder exogenous and endogenous small RNA pathways in Drosophila. [PDF]

PLoS ONE, 2009
In plants and insects, RNA interference (RNAi) is the main responder against viruses and shapes the basis of antiviral immunity. Viruses counter this defense by expressing viral suppressors of RNAi (VSRs). While VSRs in Drosophila melanogaster were shown
Bassam Berry, Safia Deddouche, Doris Kirschner, Jean-Luc Imler, Christophe Antoniewski   +4 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

RNAi technologies for insect control in crop protection

Crop Journal
RNA interference (RNAi) has been used for agricultural insect pest control based on silencing of targeted insect genes. However, the effectiveness of RNAi and its applications in insect pest control remain challenging.
Xue Zhong, Xiudao Yu, Jiahui Zhang, Jiajing Xu, Mengchao Qin, Mingxin Cao, Frédéric Francis, Lanqin Xia   +7 more
doaj   +1 more source

Convergent evolution of argonaute-2 slicer antagonism in two distinct insect RNA viruses.

PLoS Pathogens, 2012
RNA interference (RNAi) is a major antiviral pathway that shapes evolution of RNA viruses. We show here that Nora virus, a natural Drosophila pathogen, is both a target and suppressor of RNAi.
Joël T van Mierlo, Alfred W Bronkhorst, Gijs J Overheul, Sajna A Sadanandan, Jens-Ola Ekström, Marco Heestermans, Dan Hultmark, Christophe Antoniewski, Ronald P van Rij   +8 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Function and Evolution of Nematode RNAi Pathways

Non-Coding RNA, 2019
Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements.
Miguel Vasconcelos Almeida, Miguel A. Andrade-Navarro, René F. Ketting   +2 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source