Results 31 to 40 of about 835,495 (286)

The roles of RNA N6-methyladenosine in esophageal cancer

Heliyon, 2022
Esophageal cancer is a malignant tumour with a high degree of malignancy and high mortality. Its pathogenesis and treatment strategy remain unclear.
Chuan Teng, Fanhua Kong, Jinggang Mo, Weidong Lin, Chong Jin, Kunpeng Wang, Ying Wang   +6 more
doaj   +1 more source

PROBer Provides a General Toolkit for Analyzing Sequencing-Based Toeprinting Assays [PDF]

, 2017
A number of sequencing-based transcriptase drop-off assays have recently been developed to probe post-transcriptional dynamics of RNA-protein interaction, RNA structure, and RNA modification.
Aviran, Sharon, Li, Bo, Pachter, Lior, Tambe, Akshay   +3 more
core   +2 more sources

Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]

, 2012
Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter, Kötter, Peter, Lamberth, Stefanie, Peifer, Christian, Sharma, Sunny, Watzinger, Peter   +5 more
core   +1 more source

Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants [PDF]

, 2016
Despite recent advances in understanding the complexity of RNA processes, regulation of the metabolism of oxidized cellular RNAs and the mechanisms through which oxidized ribonucleotides affect mRNA translation, and consequently cell viability, are not ...
A Nunomura, AJ Kemp, C Chen, C Falcone, C Mazzoni, C Mazzoni, C Mazzoni, C Mazzoni, C Mazzoni, C Mazzoni, CK Mathews, CL Simms, Claudio Falcone, Cristina Mazzoni, D Carmona-Gutierrez, F Madeo, F Madia, F Stutz, F Taddei, H Kamiya, Joanna Kufel, Mariarita Stirpe, Matteo Ferrari, ME Schmitt, S Tharun, Seweryn Mroczek, T Hofer, T Hofer, TW Traut, V Palermo, V Palermo, V Palermo, V Palermo, Vanessa Palermo, X Shan, Y Chang, Z Li   +36 more
core   +2 more sources

RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]

, 2014
Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Aregger, Buratowski, Cansizoglu, Chook, Chu, Cowling, Cowling, Dormann, Fridell, Glover-Cutter, Gonatopoulos-Pournatzis, Lee, Li, Perales, Rebane, Shafer, Shatkin, Shuman, Suzuki, Süel, Thomas Gonatopoulos-Pournatzis, Topisirovic, Van Dusen, Victoria H. Cowling, Xu   +24 more
core   +4 more sources

Characterization of N6-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract [PDF]

International Journal of Ophthalmology
AIM: To characterize the N6-methyladenosine (m6A) modification patterns in long non-coding RNAs (lncRNAs) in sporadic congenital cataract (CC) and age-related cataract (ARC).
Hong-Fei Ye, Xiang Zhang, Zhen-Nan Zhao, Ce Zheng, Ping Fei, Yu Xu, Jiao Lyu, Ji-Li Chen, Xun-Xiang Guo, Huang Zhu, Pei-Quan Zhao   +10 more
doaj   +1 more source

Gene Expression Profile and Prognostic Value of m6A RNA Methylation Regulators in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Xian Chang,1,* Yang-Fan Lv,2,* Jing He,3,* Ya Cao,2 Chang-Qing Li,1 Qiao-Nan Guo2 1Department of Orthopedics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, People’s Republic of China; 2Department ...
Chang X, Lv YF, He J, Cao Y, Li CQ, Guo QN   +5 more
doaj  

Crosstalk Between Four Types of RNA Modification Writers Characterizes the Tumor Immune Microenvironment Infiltration Patterns in Skin Cutaneous Melanoma

Frontiers in Cell and Developmental Biology, 2022
The “writers” of four types of adenosine (A)-related RNA modifications (N6-methyladenosine, N1-methyladenosine, alternative polyadenylation, as well as A-to-inosine RNA editing) are closely related to the tumorigenesis and progression of many cancer ...
Shichao Zhang, Yu Xiong, Chaochao Zheng, Jinhua Long, Houming Zhou, Zhu Zeng, Yan Ouyang, Fuzhou Tang   +7 more
doaj   +1 more source

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

mBio, 2021
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and ...
Xueyan Zhang, Haojie Hao, Li Ma, Yecheng Zhang, Xiao Hu, Zhen Chen, Di Liu, Jianhui Yuan, Zhangli Hu, Wuxiang Guan   +9 more
doaj   +1 more source

RNA modification mapping with JACUSA2

Genome Biology, 2022
Several high-throughput antibody-free methods for RNA modification detection from sequencing data have been developed. We present JACUSA2 as a versatile software solution and comprehensive analysis framework for RNA modification detection assays that are
Michael Piechotta, Isabel S. Naarmann-de Vries, Qi Wang, Janine Altmüller, Christoph Dieterich   +4 more
doaj   +1 more source