Results 31 to 40 of about 853,838 (334)
Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in "Saccharomyces cerevisiae" [PDF]
, 2013 The 25S rRNA of yeast contains several base modifications in the functionally important regions. The enzymes responsible for most of these base modifications remained unknown.
Entian, Karl-Dieter +3 more
core +1 more source
ALKBHs-facilitated RNA modifications and de-modifications [PDF]
DNA Repair, 2016 The AlkB gene that protects E.coli against methylation damage to DNA was identified more than 3 decades ago. 20 years later, the AlkB protein was shown to catalyze repair of methylated DNA base lesions by oxidative demethylation. Two human AlkB homologs were characterized with similar DNA repair activities and seven additional human AlkB homologs were ...
Endalkachew, A Alemu +2 more
openaire +2 more sources
Instrumental analysis of RNA modifications [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2021 Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks.
Yasemin Yoluç +9 more
openaire +3 more sources
Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
Detection technologies for RNA modifications
Experimental & Molecular Medicine, 2022 AbstractTo date, more than 170 chemical modifications have been characterized in RNA, providing a new layer of gene expression regulation termed the ‘epitranscriptome’. RNA modification detection methods and tools advance the functional studies of the epitranscriptome.
Zhang, Yan, Lu, Liang, Li, Xiaoyu
openaire +2 more sources
RNA modifications in brain tumorigenesis [PDF]
Acta Neuropathologica Communications, 2020 AbstractRNA modifications are emerging as critical regulators in cancer biology, thanks to their ability to influence gene expression and the predominant protein isoforms expressed during cell proliferation, migration, and other pro-oncogenic properties.
Albert Z. Huang +2 more
openaire +3 more sources
Frontiers in Oncology, 2022 N6-methyladenosinen (m6A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m6A modification regulates RNA stability and other mechanisms, including translation, cleavage,
Gaofeng Li +7 more
doaj +1 more source
The roles of RNA N6-methyladenosine in esophageal cancer
Heliyon, 2022 Esophageal cancer is a malignant tumour with a high degree of malignancy and high mortality. Its pathogenesis and treatment strategy remain unclear.
Chuan Teng +6 more
doaj +1 more source
Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants [PDF]
, 2016 Despite recent advances in understanding the complexity of RNA processes, regulation of the metabolism of oxidized cellular RNAs and the mechanisms through which oxidized ribonucleotides affect mRNA translation, and consequently cell viability, are not ...
A Nunomura +36 more
core +2 more sources
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]
, 2012 Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter +5 more
core +1 more source