Results 41 to 50 of about 753,590 (330)
Detection technologies for RNA modifications
Experimental & Molecular Medicine, 2022 AbstractTo date, more than 170 chemical modifications have been characterized in RNA, providing a new layer of gene expression regulation termed the ‘epitranscriptome’. RNA modification detection methods and tools advance the functional studies of the epitranscriptome.
Zhang, Yan, Lu, Liang, Li, Xiaoyu
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RNA Modification in Inflammatory Bowel Diseases [PDF]
Biomedicines, 2022 Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype.
Mika Nakayama +10 more
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RNA modification of an RNA modifier prevents self-RNA sensing.
PLoS Biology, 2021 A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during
Daltry L Snider, Stacy M Horner
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ALKBHs-facilitated RNA modifications and de-modifications [PDF]
DNA Repair, 2016 The AlkB gene that protects E.coli against methylation damage to DNA was identified more than 3 decades ago. 20 years later, the AlkB protein was shown to catalyze repair of methylated DNA base lesions by oxidative demethylation. Two human AlkB homologs were characterized with similar DNA repair activities and seven additional human AlkB homologs were ...
Endalkachew Ashenafi Alemu +3 more
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Broad application of a simple and affordable protocol for isolating plant RNA [PDF]
, 2015 BACKGROUND: Standard molecular biological methods involve the analysis of gene expression in living organisms under diverse environmental and developmental conditions. One of the most direct approaches to quantify gene expression is the isolation of RNA.
Ana Arruabarrena +8 more
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Journal of Hepatocellular Carcinoma, 2021 Xian Chang,1,* Yang-Fan Lv,2,* Jing He,3,* Ya Cao,2 Chang-Qing Li,1 Qiao-Nan Guo2 1Department of Orthopedics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, People’s Republic of China; 2Department ...
Chang X +5 more
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Frontiers in Genetics, 2023 RNA modification plays important role in the occurrence and development of hepatocellular carcinoma. The best characterized RNA modification is m6A, while other kinds of RNA modifications have not been fully investigated in hepatocellular carcinoma (HCC).
Wan Qin, Chen Jin, Jun Zou
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mBio, 2021 The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and ...
Xueyan Zhang +9 more
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Frontiers in Cell and Developmental Biology, 2022 The “writers” of four types of adenosine (A)-related RNA modifications (N6-methyladenosine, N1-methyladenosine, alternative polyadenylation, as well as A-to-inosine RNA editing) are closely related to the tumorigenesis and progression of many cancer ...
Shichao Zhang +7 more
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Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. [PDF]
, 2013 DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood.
Do, Truman +7 more
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