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Export of miRNAs from activated macrophages is cooperative and HuR-dependent. [PDF]
FEBS LettGhosh S, Mukherjee K, Bhattacharyya SN.
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A Replication-Competent Flavivirus Genome with a Stable GFP Insertion at the NS1-NS2A Junction. [PDF]
Biology (Basel)Tarlykov P +8 more
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A Nonviral Neo-Nucleocapsid for Cell-Specific RNA Delivery Developed by Pseudo-Cyclic Peptide Grafting and Directed Evolution. [PDF]
Angew Chem Int Ed EnglKanayama D +4 more
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Packaging RNA drugs into extracellular vesicles
Nature Biomedical Engineering, 2020The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.
van Eijndhoven, Monique A J +2 more
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Packaged Heteroclite Subgenomic RNAs of PRRSV
2001Porcine reproductive and respiratory syndrome virus (PRRSV) is a member of the Arteriviridae family of the Nidovirales (Meulenberg et al, 1993b; Nelsen et al., 1999). While the complete genomes of three PRRSV strains are known (Allende et al., 1999; Meulenberg et al., 1993; Nelsen et al., 1999), main questions remains to be elucidated concerning viral ...
S, Yuan, M P, Murtaugh, K S, Faaberg
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Packaging of HCV-RNA into lentiviral vector
Biochemical and Biophysical Research Communications, 2011The advent of infectious molecular clones of Hepatitis C virus (HCV) has unlocked the understanding of HCV life cycle. However, packaging of the genomic RNA, which is crucial to generate infectious viral particles, remains poorly understood. Molecular interactions of the domain 1 (D1) of HCV Core protein and HCV RNA have been described in vitro.
Vincent, Caval +4 more
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Archives of Virology, 2005
A minimal bovine leukemia virus (BLV) RNA packaging sequence (E) required for heterologous RNAs to be packaged into BLV particles was analyzed. The BLV E was inserted into a non-viral vector, pLacZ, in order to determine if packaging of the non-viral vector RNA would occur. The construct was transfected into cells chronically infected with BLV in order
N A, Jewell, L M, Mansky
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A minimal bovine leukemia virus (BLV) RNA packaging sequence (E) required for heterologous RNAs to be packaged into BLV particles was analyzed. The BLV E was inserted into a non-viral vector, pLacZ, in order to determine if packaging of the non-viral vector RNA would occur. The construct was transfected into cells chronically infected with BLV in order
N A, Jewell, L M, Mansky
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2007
Publisher Summary This chapter focuses on the concept of human immunodeficiency virus type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process by which the virus negotiates the trafficking of a minority species of mRNA through a particular cellular pathway to become its genome.
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Publisher Summary This chapter focuses on the concept of human immunodeficiency virus type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process by which the virus negotiates the trafficking of a minority species of mRNA through a particular cellular pathway to become its genome.
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Structure of B77 sarcoma virus RNA: stabilization of RNA after packaging
Journal of Virology, 1975Extracellular maturation of Bratislava 77(B77) sarcoma virus RNA involves a stabilization of linkage between 35S subunits since the Tm of 60 to 70S RNA in the presence of 0.5 M NaCl increases from 56 to 67.5 C as the age of the virus increases. This stabilization process is strongly temperature dependent; the rate at 45 C is increased fourfold over the
C M, Stoltzfus, P N, Snyder
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