Results 221 to 230 of about 104,592 (252)

Revolution in an RNA-packaging capsid

Science, 2021
Directed Evolution Artificial nucleocapsid proteins, which could be analogous to those used by viruses to package their genomes, are a promising way to protect and deliver RNAs. Using an escalating challenge by nucleases, Tetter et al. evolved a protein that forms multimeric, spherical cages into a highly efficient capsid that selectively packages its ...
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Retroviral RNA packaging: a review

1994
In retroviruses, the "Gag" or core polyprotein is capable of assembling into virus particles and packaging the genomic RNA of the virus. How this protein recognizes viral RNA is not understood. Gag polyproteins contain a zinc-finger domain; mutants with changes in this domain assemble into virions, but a large fraction of these particles lack viral RNA.
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Retroviral RNA Packaging: Sequence Requirements and Implications

1990
Unlike many animal viruses, infection by retroviruses generally does not lead to cessation of host RNA synthesis. Despite the high levels of host RNA in infected cells, the vast majority of retroviral particles contain a precise genomic complex consisting of two molecules of genomic RNA, rather than cellular or subgenomic viral mRNAs.
M L, Linial, A D, Miller
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Genome Packaging by Spherical Plant RNA Viruses

Annual Review of Phytopathology, 2006
Abstract  The majority of positive-strand RNA viruses of plants replicate and selectively encapsidate their progeny genomes into stable virions in cytoplasmic compartments of the cell where the opportunity to copackage cellular RNA also exists. Remarkably, highly purified infectious virions contain almost exclusively viral RNA, suggesting that ...
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RNA Secondary Structure Analysis Using the Vienna RNA Package

Current Protocols in Bioinformatics, 2003
AbstractThis Current Protocols in Bioinformatics unit documents how to use the Vienna RNA package for RNA secondary structure analysis. Possible tasks include structure prediction for single sequences, prediction of consensus structures, and sequence design.
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Nucleic Acid Packaging of RNA Viruses

2006
Viruses are obligate intracellular parasites composed of virus-specific nucleic acid and a protective coat. During virus assembly, the critical stage is the specific recognition of the viral genome with the maturing virus capsid leading to encapsidation (packaging) of the genome to the protective capsid.
Markus Jaakko Pirttimaa, Dennis Henry Bamford   +1 more
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HIV RNA packaging and lentivirus-based vectors

2000
Since the mid-1990s, the number of publications on lentivirus-based vectors has expanded dramatically as people have realized the opportunity that they represent. High-titer helper-virus free transfer of genes to nondividing cells is a reality and it can only be a short time before clinical trials are initiated.
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Retroviral RNA packaging

Biochemical Society Transactions, 1991
A M, Lever, J H, Richardson, G P, Harrison   +2 more
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RNA Packaging

1996
R, Berkowitz, J, Fisher, S P, Goff
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Cellular functions of eukaryotic RNA helicases and their links to human diseases

Nature Reviews Molecular Cell Biology, 2023
Katherine E Bohnsack, Eckhard Jankowsky, Markus T Bohnsack   +2 more
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