Results 1 to 10 of about 991,885 (339)
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
Nature, 2023 Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites and has been proposed to regulate transcription initiation^ 1 , 2 .
Hua Wang +6 more
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RNA polymerase II at initiation [PDF]
Proceedings of the National Academy of Sciences, 2003 RNA polymerase II (RNAPII) is the enzyme responsible for synthesis of all mRNA in higher cells. As the central component of the eukaryotic transcription machinery, RNAPII is the final target of regulatory pathways that are ultimately responsible for cellular development, differentiation, and metabolic control.
Francisco J. Asturias, John L. Craighead
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A Movie of RNA Polymerase II Transcription [PDF]
Cell, 2012 We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition.
Cheung, A.C.M., Cramer, P.
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The Mediator complex as a master regulator of transcription by RNA polymerase II
Nature reviews. Molecular cell biology, 2022 The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits, controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining feature of Mediator is its intrinsic disorder and conformational flexibility,
William F. Richter +3 more
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RNA Polymerase II: Just Stopping By [PDF]
Cell, 2007 In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polymerase at transcription start sites in the human genome. Their results reveal that many "inactive" genes harbor histone marks associated with active transcription at their 5' ends and that although these genes initiate transcription, they do not generate ...
Dirk Schübeler, Matthew C. Lorincz
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Structure of an inactive RNA polymerase II dimer [PDF]
Nucleic Acids Research, 2021 Abstract Eukaryotic gene transcription is carried out by three RNA polymerases: Pol I, Pol II and Pol III. Although it has long been known that Pol I can form homodimers, it is unclear whether and how the two other RNA polymerases dimerize.
Shintaro Aibara +2 more
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RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
EMBO Journal, 2021 RNA polymerase II (RNA Pol II) speed or elongation rate, i.e., the number of nucleotides synthesized per unit of time, is a major determinant of transcriptome composition.
Lisa Muniz, Estelle Nicolas, D. Trouche
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RNA Polymerase II Elongation Control [PDF]
Annual Review of Biochemistry, 2012 Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized extensively to generate the pattern of mRNAs needed to specify cell types and to respond to environmental changes. After Pol II initiates, negative elongation factors cause it to pause in a promoter proximal position. These polymerases are poised to respond to
Qiang Zhou, Tiandao Li, David H. Price
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Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Science, 2018 Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered low-complexity ...
W. Cho +6 more
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Genes & Development, 2000 The activities of several mRNA processing factors are coupled to transcription through binding to RNA polymerase II (Pol II). The largest subunit of Pol II contains a repetitive carboxy-terminal domain (CTD) that becomes highly phosphorylated during ...
P. Komarnitsky, E. Cho, S. Buratowski
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