Widespread epistasis shapes RNA polymerase II active site function and evolution [PDF]
Nature CommunicationsMulti-subunit RNA Polymerases are responsible for transcription in all kingdoms of life. These enzymes rely on dynamic, highly conserved active site domains such as the so-called “trigger loop” to accomplish steps in the transcription cycle. Mutations in
Bingbing Duan +3 more
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Multi-omics analysis reveals RNA polymerase II degradation as a novel mechanism of PF-3758309's anti-tumor activity. [PDF]
Cell Death DiscovJia X +11 more
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Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
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RNA polymerase II pausing in development: orchestrating transcription
Open Biology, 2022 The coordinated regulation of transcriptional networks underpins cellular identity and developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) is a prevalent mechanism by which cells can control and synchronize ...
Abderhman Abuhashem +2 more
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High resolution mapping of enhancer-promoter interactions. [PDF]
PLoS ONE, 2015 RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for analyzing ChIA-PET data, the ChIA-PET
Christopher Reeder +5 more
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Genome-wide mapping of yeast RNA polymerase II termination. [PDF]
PLoS Genetics, 2014 Yeast RNA polymerase II (Pol II) terminates transcription of coding transcripts through the polyadenylation (pA) pathway and non-coding transcripts through the non-polyadenylation (non-pA) pathway.
Paul Schaughency +2 more
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Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
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A remodeled RNA polymerase II complex catalyzing viroid RNA-templated transcription.
PLoS Pathogens, 2022 Viroids, a fascinating group of plant pathogens, are subviral agents composed of single-stranded circular noncoding RNAs. It is well-known that nuclear-replicating viroids exploit host DNA-dependent RNA polymerase II (Pol II) activity for transcription ...
Shachinthaka D Dissanayaka Mudiyanselage +5 more
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MDC1 maintains active elongation complexes of RNA polymerase II
Cell Reports, 2023 Summary: The role of MDC1 in the DNA damage response has been extensively studied; however, its impact on other cellular processes is not well understood.
George Pappas +14 more
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Structure of the p53/RNA polymerase II assembly
Communications Biology, 2021 Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II ...
Shu-Hao Liou +4 more
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