Results 1 to 10 of about 502,586 (144)
Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
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Widespread epistasis shapes RNA polymerase II active site function and evolution [PDF]
Nature CommunicationsMulti-subunit RNA Polymerases are responsible for transcription in all kingdoms of life. These enzymes rely on dynamic, highly conserved active site domains such as the so-called “trigger loop” to accomplish steps in the transcription cycle. Mutations in
Bingbing Duan +3 more
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RNA polymerase II pausing in development: orchestrating transcription
Open Biology, 2022 The coordinated regulation of transcriptional networks underpins cellular identity and developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) is a prevalent mechanism by which cells can control and synchronize ...
Abderhman Abuhashem +2 more
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High resolution mapping of enhancer-promoter interactions. [PDF]
PLoS ONE, 2015 RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for analyzing ChIA-PET data, the ChIA-PET
Christopher Reeder +5 more
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Genome-wide mapping of yeast RNA polymerase II termination. [PDF]
PLoS Genetics, 2014 Yeast RNA polymerase II (Pol II) terminates transcription of coding transcripts through the polyadenylation (pA) pathway and non-coding transcripts through the non-polyadenylation (non-pA) pathway.
Paul Schaughency +2 more
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Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
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RNA polymerase II at initiation [PDF]
Proceedings of the National Academy of Sciences, 2003 RNA polymerase II (RNAPII) is the enzyme responsible for synthesis of all mRNA in higher cells. As the central component of the eukaryotic transcription machinery, RNAPII is the final target of regulatory pathways that are ultimately responsible for cellular development, differentiation, and metabolic control.
Francisco J, Asturias, John L, Craighead
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RNA Polymerase II Elongation Control [PDF]
Annual Review of Biochemistry, 2012 Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized extensively to generate the pattern of mRNAs needed to specify cell types and to respond to environmental changes. After Pol II initiates, negative elongation factors cause it to pause in a promoter proximal position. These polymerases are poised to respond to
Qiang, Zhou, Tiandao, Li, David H, Price
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A remodeled RNA polymerase II complex catalyzing viroid RNA-templated transcription.
PLoS Pathogens, 2022 Viroids, a fascinating group of plant pathogens, are subviral agents composed of single-stranded circular noncoding RNAs. It is well-known that nuclear-replicating viroids exploit host DNA-dependent RNA polymerase II (Pol II) activity for transcription ...
Shachinthaka D Dissanayaka Mudiyanselage +5 more
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Dephosphorylating eukaryotic RNA polymerase II [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2016 The phosphorylation state of the C-terminal domain of RNA polymerase II is required for the temporal and spatial recruitment of various factors that mediate transcription and RNA processing throughout the transcriptional cycle. Therefore, changes in CTD phosphorylation by site-specific kinases/phosphatases are critical for the accurate transmission of ...
Joshua E, Mayfield +2 more
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