Results 11 to 20 of about 946,604 (388)
CDK9-dependent RNA polymerase II pausing controls transcription initiation
eLife, 2017 Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear.
Saskia Gressel +6 more
doaj +2 more sources
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
Nature, 2023 Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites and has been proposed to regulate transcription initiation^ 1 , 2 .
Hua Wang +6 more
semanticscholar +1 more source
The Mediator complex as a master regulator of transcription by RNA polymerase II
Nature reviews. Molecular cell biology, 2022 The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits, controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining feature of Mediator is its intrinsic disorder and conformational flexibility,
William F. Richter +3 more
semanticscholar +1 more source
Genetic dissection of the RNA polymerase II transcription cycle
eLife, 2022 How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during transcription remains poorly understood. Here, we used naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences affect the ...
Shao-Pei Chou +4 more
doaj +1 more source
Structure of the p53/RNA polymerase II assembly
Communications Biology, 2021 Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II ...
Shu-Hao Liou +4 more
doaj +1 more source
Structure of an inactive RNA polymerase II dimer [PDF]
Nucleic Acids Research, 2021 Abstract Eukaryotic gene transcription is carried out by three RNA polymerases: Pol I, Pol II and Pol III. Although it has long been known that Pol I can form homodimers, it is unclear whether and how the two other RNA polymerases dimerize.
Shintaro Aibara +2 more
openaire +5 more sources
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
EMBO Journal, 2021 RNA polymerase II (RNA Pol II) speed or elongation rate, i.e., the number of nucleotides synthesized per unit of time, is a major determinant of transcriptome composition.
Lisa Muniz, Estelle Nicolas, D. Trouche
semanticscholar +1 more source
Chromatin remodeling by Pol II primes efficient Pol III transcription
Nature Communications, 2023 The packaging of the genetic material into chromatin imposes the remodeling of this barrier to allow efficient transcription. RNA polymerase II activity is coupled with several histone modification complexes that enforce remodeling.
Carlo Yague-Sanz +6 more
doaj +1 more source
A comparative study of DNA-dependent RNA polymerases from rat ascites hepatoma cell nuclei and from rat liver nuclei [PDF]
, 1975 DNA-dependent RNA polymerases (EC 2.7.7.6) were extracted and partially purified form the nuclei of rat ascites hepatoma cells (AH-130) induced by 4-dimethylaminoazobenzene.
Misumi, Hiromasa
core +1 more source
Nucleic Acids Research, 1983 We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters.
J. Dignam, R. Lebovitz, R. Roeder
semanticscholar +1 more source